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1、HindawiPublishingCorporationAdvancesinVirologyVolume2011,ArticleID609465,11pagesdoi:10.1155/2011/609465ReviewArticleFelineandCanineCoronaviruses:CommonGeneticandPathobiologicalFeaturesSophieLePoderUMR1161INRA-ENVA-ANSES,7avenueG´en´eraldeGaulle,94704Maisons-Alfort,FranceCorrespondenceshouldbead
2、dressedtoSophieLePoder,slepoder@vet-alfort.frReceived12December2010;Revised3March2011;Accepted18May2011AcademicEditor:PeterJ.M.RottierCopyright©2011SophieLePoder.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductio
3、ninanymedium,providedtheoriginalworkisproperlycited.Anewhumancoronavirusresponsibleforsevereacuterespiratorysyndrome(SARS)wasidentifiedin2003,whichraisedconcernaboutcoronavirusesasagentsofseriousinfectiousdisease.Nevertheless,coronaviruseshavebeenknownforabout50yearstobemajoragentsofrespiratory,
4、enteric,orsystemicinfectionsofdomesticandcompanionanimals.Felineandcaninecoronavirusesarewidespreadamongdogandcatpopulations,sometimesleadingtothefataldiseasesknownasfelineinfectiousperitonitis(FIP)andpantropiccaninecoronavirusinfectionincatsanddogs,respectively.Inthispaper,differentaspectsofthe
5、genetics,hostcelltropism,andpathogenesisofthefelineandcaninecoronaviruses(FCoVandCCoV)willbediscussed,withaviewtoillustratinghowstudyofFCoVsandCCoVscanimproveourgeneralunderstandingofthepathobiologyofcoronaviruses.1.IntroductionfamilyCoronaviridae,thatis,thefelinecoronavirus(FCoV)[10].Thefirstob
6、servationofcaninecoronavirus(CCoV)Coronavirusesareenvelopedviruseswithalarge(27–infectionwasreportedin1971,whenBinnandcolleagues32kb)single-stranded,positive-senseRNA[1].Thegenomeisolatedacoronavirus(strain1-71)fromdogswithacuteincludesatleast6openreadingframes(ORFs)flankedbyenteritisinamilitary
7、canineunitinGermany[11].Since5and3untranslatedregions.TheviralRNAispackagedthesediscoveries,muchknowledgehasbeengainedasbythenucleocapsidprotein(N),whicharethemselvesregardingthemolecularbiologyandpathobiologyoftheseenclosedinan
