冠状病毒Coronavirusl论文-2005 Association Between a Novel Human Coronavirus and Kawasaki Disease (1).pdf

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1、CURRENTABSTRACTSEditedby:RobertJ.Leggiadro,MDhighdose
-lactamadministration,neuromuscularblockadeofami-NonantimicrobialEffectsofAntibacterialAgentsnoglycosides,dysglycemiaoffluoroquinolonesandserotoninsyn-R.PasqualeandJ.Tan.ClinInfectDis2005;40:127–135dromewithoxazolidinon

2、es.Thenonantimicrobialtherapeuticactivitiesderivedfromknownsideeffectsofantimicrobialagentsarereviewed.Forexample,sulfon-amide-relatedagentsthatlackantimicrobialactivityarecommonlyTularemiaAssociatedwithaHamsterBite:Colorado,2004usedforhypoglycemiceffect(sulfonylureas)and

3、carbonicanhy-CentersforDiseaseControlandPrevention.MMWR.2005;53:draseblockade(acetazolamide).1202–1203.Nonantibacterialeffectsofmacrolidesincludegastrointesti-TheColoradoDepartmentofPublicHealthandEnvironmentwasnalmotilityandimmunomodulation.Clinicalstudiessuggestthatnoti

4、fiedabouta3-year-oldboydiagnosedwithtularemiaassociatederythromycinandother14-membermacrolidesactasmotilinrecep-withapethamster.Sixhamstersthathisfamilyhadpurchasedfromtoragonists.Motilin,anaminoacidpeptide,isbelievedtoplayaapetstoreintheDenvermetropolitanareaduringthewint

5、erof2004roleincontrollingthecyclicburstsofcontractileactivitythatoccurdiedwithin1weekofpurchase.Onehamsterbitthechildontheleftinthegastrointestinaltractduringthefastingstate.Erythromycinringfingershortlybeforeitdied.Thechilddevelopedfever,malaise,andothermacrolidesalsohave

6、beneficialimmunomodulatoryef-painfulleftaxillarylymphadenopathyandskinsloughingatthebitefects.Theseantibioticshavebeenfoundtobebeneficialinthesite7dayslater.Tissuecultureofaleftaxillarylymphnodetreatmentofhypersecretoryconditions,suchasdiffusepanbronchi-excisionalbiopsyspec

7、imenyieldedaFrancisellatularensisisolate,olitisandcysticfibrosis.andconvalescentserologywaspositiveatatiterof4096.ThepatientAlthoughthemechanismbywhichmacrolidesareeffec-improvedaftertreatmentwithciprofloxacin.Nootherriskfactorstiveinthetreatmentofhypersecretoryconditionsis

8、notcom-fortularemiaexposurewereidentified,includingnootheranimalpletelyunderstood,severaltheories