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1、ForewordbyK.BarrySharplessProcesschemistsareabreedapart.Whiletheirbackgroundsmayvary,theyshareacommonpreoccupationwithunderstandingchemicalreactivity.Thebestonesseemabletoanticipatemuchofwhatcangowronginaproposedreactionsequence,andthusavoidmostofthetraps,barriers,anddeadends
2、thatimpedetherestofus.Theygainprofoundsatisfactionfrombeingabletosteeracomplexreactionalongoneofmanypossiblepaths,creatingthesense,albeitwhimsical,ofwielding"poweroverthemolecules."Theprocesschemist'sspecialsenseforwhichreactionvariablesofferthemostleverageinagivencaseisfound
3、edontheabilitytoabsorbvastamountsofinfor-mationaboutfactorsthataffectreactivityandtosortthemintoacoherentandflexible"intuition."Information,boththeoreticalandempiricalinnature,iscon-tinuouslyaddedandintuitionisthuscontinuouslyrefined.Itisthereforevirtuallyimpossibleforayoungp
4、rocesschemisttoavoidlearningmanycruciallessonsthehardway.Wheneverold-timersareinthemoodforgivingout"tips"(videinfra),Ialwayspayattention.Processchemiststhusplayacrucialroleinadvancingbothbasicandappliedchemistry.Giventhatman-madechemicalproductswouldnotexistwithouttheirskills
5、,itisoddandunfortunatethattheyrarelyhavemuchsayinselectingthemoleculartargetsforwhichtheymustdevisepracticalcommercialsyntheses.Nowhereistheexclusionofprocesschemistsfromthediscoveryprocessmoreunfortunatethaninthepharmaceuticalindustry.Herediscoverytakestheformofa"sky's-the-l
6、imit"search,whereinchemistrythatisfeasible,letaloneideal,forapplicationonapracticalscaleisallbutignored.Thepharmaceuticalindustrythereforeneedsmoreprocesschemiststhananyotherfield,andthechallengestheyfacearebyfarthemostdauntingofchemistsinanyareaofpureorappliedchemistry.NealA
7、nderson,oneoftheoutstandingpractitionersofpharmaceuticalprocessresearchanddevelopment,hasgivenusherethebesttexteverwrittenontheXVxviForewordbyK.BarrySharplesssubject.Thisaccomplishmentisallthemoreimpressivebecausetheaforemen-tioned"noholdsbarred"chemistrystylefavoredbythedisc
8、overyteammeansthattheprocesschemisthastobereadyandwillingtodealwitho