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1、上皮性卵巢癌病人血清uPA、uPAR和CA125含量检测及其临床意义【摘要】目的探讨上皮性卵巢癌病人血清中尿激酶熨纤溶酶原激活物(uPA)及其受体(uPAR)和糖蛋白抗原125(CA125)含量的变化及其临床意义。方法采集44例上皮性卵巢癌(卵巢癌组)、35例卵巢良性上皮性肿瘤(良性肿瘤组)和30例止常卵巢(対照纽)病人血淸标本，用ELISA方法检测血淸中uPA、uPAR含量，化学发光法检测血清CA125含量。结果卵巢癌纽.uPA、uPAR和CAI25的分泌水平较良性肿瘤组及对照组明显升高,差异有显著性(
2、F=9.49〜4824.97,q=5.183〜119.350,PvO.OI)；良性肿痫组与对照组齐指标比较差异无统计学意义(P>0.05)o卵巢癌纽uPA、uPAR和CA125的分泌水平随着手术病理分期的増高及纽织分化程度的降低血増高，差异有显著性(F=15.00〜649.46,q=4.467〜56.536,PvO.Ol)。卵巢癌纽有淋巴结和(或)大网膜转移者中uPA和uPAR含量较无转移者明显增高，差异有极显著性(匸&445〜18.60&PvO.Ol)。卵巢癌病人血淸uPA、uPAR和CA125联合检测
3、的阳性率和敏感度较血淸CA125用一检测升高，差异有显著意义(X2=3.123,PvO.05)。结论联合检测血清中uPA、uPAR和CA125的含杲，对判断卵巢癌的发生发展、浸润和转移有重要意义。【关键词】卵巢肿瘤;尿纤溶酶原激活物;uPAR;CA125抗原DETECTIONOFSERUMuPA,uPARANDCAI25INPATIENTSWITHEPITHELIALOVARIANCANCERLINHUI,SHANFENG,WANGXIANGYU,etal(DepartmentofGynecology,T
4、heAffiliatedHospitalofQingdaoUniversityMedicalCollege,Qingdao266003,China);[ABSTRACT]ObjectiveToexploretheclinicalsignificanceofthechangesofserumlevelsofurokinasetypeplasminegenactivator(uPA),uPAreceptor(uPAR)andCAI25inpatientswithepithelialovariancancer(
5、EOC).MethodsSerumsampleswerecollectedfrom44patientswithEOC,35withbenignovarianepithelialtumors(BOET)and30normalcontrols・ELISAwasusedtodetecttheuPAanduPAR,andbiochemicalcolorimetricmethodtodetectCAI25・ResultsThelevelsofuPA,uPARandCAI25inthecancerpatientswe
6、resignificantlyhigherthanthoseofbenignandnormalcontrols(F=9.49-4824.97,q=5.183・119.350,PvO.Ol).Butthedifferencesbetweenbenigntumorandnormalcontrolswerenotstatisticallysignificant(P>0.05).ThelevelsofuPA,uPARandCAI25inthecancerincreasedwiththeelevationofpat
7、hologystaginganddegradingofhistologydifferentiation(F=15.00-649.46,q=4.467-56.536,PvO.Ol),thelevelsofuPA,uPARandCAI25weredramaticallyelevatedinthosewithlymphnolleand/oromentummetastasis(t=8.445-18.608,P<0.01).Thepositiverateandsensitivitywerehigherbycombi
8、neddetectionofuPA,uPARandCA125thanbydetectionofCA125alone(χ2=3.123,Pv0.05).ConclusionAsimultaneousdeterminationofsemmlevelsofuPA,uPARandCAI25isofgreatsignificanceinthejudgementoftheoccurrence,development,infiltr
