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1、聚乙二醇4000联合莫沙比利治疗老年功能性便秘疗效分析杨柏霖袁昌文南京屮医药大学附属医院江苏省南京市210029通讯作者：杨柏霖，210001,江苏省南京市，南京中医药大学附属医院，E-mail：blyang1971@163.com收稿日期：接受口期：TherapeuticeffectofPEG4000combinedwithMosaprideonelderlyfunctionalconstipationsBolinYang,ChangwenYuan,ThehospitalaffiliatedofNanjin
2、gUniversityofTCM,Nanjing210029,Jiangsu,ChinaCorrespondenceto:D匚BolinYang,ThehospitalaffiliatedofNanjingUniversityofTCM,Nanjing210029,Jiangsu,China.E-mail：blyangl971@163.comReceived:Accepted:[Abstract]AIM:ToevaluatetheefficacyofPEG4000combinedwithMosapridefo
3、rthetreatmentofelderlyfunctionalconstipations.METHODS:76olderpatientswithfunctionalconstipationwereincludedandallocatedtotherapeuticgroup(n=45)orthecontrolgroup(n=31).AllpatientsreceivedPEG4000lOmg,twiceaday；TherapeuticgroupalsoreceivedMosapride5mg,threetim
4、esperday.Therapeuticoutcomesandside-effectswereevaluatedatfellow-upof2weeksand4weeksrespectively.RESULTS:Althoughtherewerenosignificantdifferenceintotaleffectiverate(91.1%vs.86.7%,95.6%vs.90.0%)andthehardpelletystoolswerechangedtosoftorthinstools(68.9%vs.63
5、.3%,77.8%vs.63.3%)inpaties,thereweresignificantdifferenceintheexcellentratebetweentwogroup(68.9%vs.46.7%,p=0.046；84.4%vs.63.3%,p=0.001)atfellow-upof2weeksand4weeksaftertreatmentrespectively.Therewerenoside-effectsduringthetreatmentperiod.CONCLUSION:UseofPEG
6、4000combinedwithMosapridetreatingelderlyfunctionalconstipationsiseffectiveandsafemethod.KeyWords:PEG4000;Mosapride;elderlyfunctionalconstipationsYangBL,YuanCW.TherapeuticeffectofPEG4000combinedwithMosaprideonelderlyfunctionalconstipations.ShijieHuarenXiaohu
7、aZazhi［摘要］目的评价聚乙二醇4000联合莫沙比利治疗老年功能性便秘的疗效。方法76例老年功能性便秘患者被随机分为两组。治疗组45例，口服聚乙二醇400010g,每日2次，莫沙比利5mg,每日3次；对照组31例，口服聚乙二醇400010g,每日2次，疗程4周。分别与第2周和第四周记录患者治疗情况，并观察药物不良反应。结果治疗2周后，治疗组和对照组粪便性状恢复正常者为68.9%心63.3%；4周时治疗组和对照组粪便性状恢复正常为77.8%w.63.3%,组间比较差异均无统计学意义。治疗2周时治疗组和对照组
8、的总有效率为91.1%w・86.7%(P=0.225),4周时总有效率为95.6%V5.90.0%(P=0.182)；但2周和4周显效率比较差异有统计学意义(68.9%皿46.7%,P=0.046；84.4%rv.63.3%,P=().0()l)o治疗期间，除对照组一例患者因自觉不适退出，两组均未发生明显不良反应。结论聚乙二醇4000联合莫沙比利治疗老年功能性便秘安全、有效，其疗效明显优于单纯使用聚
