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1、TPS、CEA和CYFRA21-1联合检测在肺癌屮的临床价值【摘要】目的探讨肺癌患者血清屮纟H.织多肽特异性抗原(TPS)、癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA21-1)的临床应用价值。方法应用ELISA法分别检测60例肺癌患者，54例良性肺部疾病和40名健康成人血清中TPS、CYFRA21-1和CEA水平，并对28例肺癌患者进行术后1个月和3个月的随访检测。结果肺癌组血清屮TPS、CEA和CYFRA21-1水平明显高于良性肺疾病组和健康对照组(P〈0.05)。3种肿瘤标志物单项检测时，以TPS的敏感性(78.3%)和准确
2、性(82.5%)最高；多项指标联合检测时，以TPS+CEA+CYFRA21-1组合获得的敏感性(95.0%)和准确性(85.1%)最高,但特异性有所降低。3种肿瘤标志物水平随临床分期(TNM)增加而升高，I、II期和III期比较,TPS和CEA差异有统计学意义(P<0.05),I、II期和IV期比较,TPS、CEA和CYFRA21-1差异均有统计学意义(PC0.05)。手术治疗后,3种肿瘤标志物均较术前明显下降。结论3种肿瘤标志物在肺癌的诊断治疗屮，具有一定的临床应用价值。TPS+CEA+CYFRA21-1纽.合可明显提高肺癌诊断的敏感
3、性和准确性。【关键词】肿瘤标记物；肺肿瘤；组织多肽特异性抗原；癌胚抗原；细胞角蛋白19片段TheclinicalvalueofcombineddeterminationofthreetumormarkersinlungcancerGUOShang-de*,WANGZhong-yiLIUHonget.al(*InstituteofRespiratoryandOccupationalDisease,ShanxiDatongUniversity,Datong,Shanxi037009,China)【Abstract]ObjectiveToin
4、vestigatetheclinicalvalueofcombineddeterminationoftissuepolypeptidespecificantigen(TPS),cytokeratinT9-fragments(CYFRA21-1)andcareinoembryonicantigen(CEA)inlungcancerpatients・MethodsTheconcentrationofthreetumormarkersinserumwasdetectedbyEIJSAin60lungcancerpa/tients,54beni
5、gnlungdiseasepatientsand40healthypeople.Moreoverfollow-upvisitwasundertakenatonemonthandthreemonthsaftersurgeryforlungcancerpatienIs.ResultsThelevelofTPS,CEAandCYFRA21-1waslsignificantlyhigherinlungcancerthanthatinbenign1ungdiseaseandhealthcontrols(P<0.05)・TPSshowedthehi
6、ghestsensitivity(7&3%)andaccuracy(82.5%)insingletumormarkerdetection,andTPS+CEA+CYFRA21-1showedthehighestsensitivity(95.0%)andaccuracy(85.1%)incombinedtumormarkerdetectionfordiagnosisoflungconcerinserum・ThevalueofTPS,CEAandCYFRA21Tchangedinrelationshiptostageofdisease・Th
7、erewerestatisticallysignificantintheserumlevelofTPSandCEAbetweenstageI,IIandstageIII(P<0.05).WealsofoundthelevelofTPS,CEAandCYFRA21TinstageIVwasevidentlyhigherthanthatinstageI,II.Afteroperation,amarkeddecreaseinthesevalueswereobserved.Itmaybeusedforassessingcurativeeffec
8、tafter-operation.ConelusionTherewasspecificallyclinicalapplicationvalueofthesethreetumormarkersfordiagn
