辅酶一(NAD)与老年化疾病.ppt

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1、Age-relateddiseasesandcancerAge-relateddiseasesCOENZYMEIP-1CONTENTSA.NADbiosyntheticpathwaysandmetabolismB.NADconsumingenzymesinhealthanddiseaseC.Age-relateddiseasesandcancerD.MechanismsofNADPrecursorsinhumansandanimalmodelsE.NADandthehallmarksofagingP-2A.NADbi

2、osyntheticpathwaysandmetabolismP-3NADbiosyntheticpathwaysandmetabolismEricVerdin.(2015).SpecialSection350（6265）:1208-1213.P-4NADbiosyntheticpathwaysandmetabolismindifferentcellularcompartments.B.NADconsumingenzymesinhealthanddiseaseP-5NADconsumingenzymesinhealt

3、handdiseaseEF.Fang,.(2017).NAD+:akeymetabolicregulatorwithgreattherapeuticpotential:1120-1143.P-6NADavailabilitycaninfluencetheactivityofthreegroupsofmasterregulatorenzymesthesirtuins,thePARPsandcyclicADP-ribosesynthases.Eachgroupofenzymesregulatemanybiological

4、processesandcanthuscouplechangesinNADlevelswithawiderangeofphysiologicalresponses.C.Age-relateddiseasesandcancerP-71980s1930s……P-8Age-relateddiseasesandcancercouldbetheconsequenceofadeclineinNAD+concentrationsAmandaGarrido(2017).Trendincancer181:181-199.Age-rel

5、ateddiseasesandcancerMetabolicsyndromeincludingcardiovasculardisorders,type2diabetesandobesity,NeurodegenerativediseasessuchasAlzheimerandParkinsondiseases,arthritis,andosteoporosis,andcanceraresomeofthediseasesthatcommonlyaffecthumanhealthduringaging.D.Benefit

6、sandmechanismsofNADprecursorsinhumansandanimalmodelsP-9BenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918P-10BenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolec

7、ularMedicine23（10）:900-918P-11BenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918P-12E.NADandthehallmarksofagingP-13NADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918P-

8、14NADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918P-15NADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23（10）:900-918P-15NAD