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ID:48037705
大小:4.16 MB
页数:18页
时间:2020-01-11
《辅酶一(NAD)与老年化疾病.ppt》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、Age-relateddiseasesandcancerAge-relateddiseasesCOENZYMEIP-1CONTENTSA.NADbiosyntheticpathwaysandmetabolismB.NADconsumingenzymesinhealthanddiseaseC.Age-relateddiseasesandcancerD.MechanismsofNADPrecursorsinhumansandanimalmodelsE.NADandthehallmarksofagingP-2A.NADbi
2、osyntheticpathwaysandmetabolismP-3NADbiosyntheticpathwaysandmetabolismEricVerdin.(2015).SpecialSection350(6265):1208-1213.P-4NADbiosyntheticpathwaysandmetabolismindifferentcellularcompartments.B.NADconsumingenzymesinhealthanddiseaseP-5NADconsumingenzymesinhealt
3、handdiseaseEF.Fang,.(2017).NAD+:akeymetabolicregulatorwithgreattherapeuticpotential:1120-1143.P-6NADavailabilitycaninfluencetheactivityofthreegroupsofmasterregulatorenzymesthesirtuins,thePARPsandcyclicADP-ribosesynthases.Eachgroupofenzymesregulatemanybiological
4、processesandcanthuscouplechangesinNADlevelswithawiderangeofphysiologicalresponses.C.Age-relateddiseasesandcancerP-71980s1930s……P-8Age-relateddiseasesandcancercouldbetheconsequenceofadeclineinNAD+concentrationsAmandaGarrido(2017).Trendincancer181:181-199.Age-rel
5、ateddiseasesandcancerMetabolicsyndromeincludingcardiovasculardisorders,type2diabetesandobesity,NeurodegenerativediseasessuchasAlzheimerandParkinsondiseases,arthritis,andosteoporosis,andcanceraresomeofthediseasesthatcommonlyaffecthumanhealthduringaging.D.Benefit
6、sandmechanismsofNADprecursorsinhumansandanimalmodelsP-9BenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23(10):900-918P-10BenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolec
7、ularMedicine23(10):900-918P-11BenefitsandmechanismsofNADprecursorsinhumansandanimalmodelsGSultani.(2017).TrendsinMolecularMedicine23(10):900-918P-12E.NADandthehallmarksofagingP-13NADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23(10):900-918P-
8、14NADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23(10):900-918P-15NADandthehallmarksofagingGSultani.(2017).TrendsinMolecularMedicine23(10):900-918P-15NAD
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