安捷伦LCMS操作.pdf

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1、DevelopmentoftheWorldtheWorlds’sMostMostLC/MSDivisionSensitiveandAgilentLabsAgilentTechnologiesTripleQuadMSTripleQuadMSSantaClara,CANew6490-World’sMostSensitiveLC/QQQiFunnelTechnology¾AgilentJetStream¾Hexaborecapillary¾Dual-stageionfunnelCollisionCel

2、l–hexapole¾Taperedstructureforincreasedionacceptance¾ReductionofbackgroundnoiseImprovedQuadDriveElectronicsImprovedQuadDriveElectronics¾HigherRFpowercapability¾Quaddrivefrequencyincreasedto1.4MHz2NEWIFUNNELTECHNOLOGYiFunnelTechnologycaptures10Xmoreio

3、nsAgilentJetStreamHexaboreCapillaryDualIonFunnel•Thermalconfinement•6capillaryinlets•RemovesthegasbutofESIplume•Samples6Xmoreionrichcapturestheions•Efficientdesolvationtogasfromthesourcegasfromthesource•RemovesneutralnoiseRemovesneutralnoisecreategas

4、phaseions•Capturesthemajorityof•Extendsturbopumplife•Createsanionrichzonethegasfromthesourceregion3AgilentJetStreamIonGenerationGasDynamicsViewNbliiNebulizinggasEnhancedefficiencynebulizerSuper-hdheatedshhheathgasNozzlevoltageHeateddryinggasTheesupes

5、uper-heatedeatedseatgassheathgascollimatesthenebulizersprayandResistivesamplingcreatesadramatically“brightersource”capillaryPatentPendingAgilent’sHexaboreAtmosphericSampling….TheMostSensitive….ByFar.6BoreCapillary•Nearly6xtheamountofatmosppgphericgas

6、sampledcomparedtoasinglecapillarysystemAND•5-10xmoreionsintothehiggghvacuumregionButhowdowehandlealltheextragasmolecules?5NeedforGreaterIonSamplingCapacity•ManyionsformedinthecollimatedAgilentJetStreamplumearestillnotcapturedbytheMSsystem•Ionssampled

7、byasinglecapillarywitha600µmi.d.•Maximumiongenerationoccursacrossa3-5mmhorizontalregionatthtthecenteroffththeplume.HexaboreSamplingCapillary•Hexaboresamplingcapillaryincreasesionsamplingefficiencyabout6Xionsamplingefficiencyabout6Xcomparedtosinglebor

8、eIonsamplinggainsaremostIonsamplinggainsaremostdramaticwiththecombinationofbothAgilentJetStreamtechnologywiththehexaboresamppglingcapillaryAgilent’sTwoStageIonFunnelCanHandletheGasLoadHihHighLowPressurePressureStage1Stage2ExistingRFIonGuideStage2Stag