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1、'DepartmentofRehabilitation.QiluHospitalofShandongUniversity・Ji'nan250012,ShandongProvince,China;departmentofNeurology.ShandongDisabledRehabilitationCenter.Ji'nan2501()0,ShandongProvince,ChinaCuiGui-xiang・Chiefphysician.DepartmentofRehabilitation,QiluHospitalofShan
2、dongUniversity.Ji'nan250012.ShandongProvince・Chinacuigx.sdhe@163.comCorrespondence(o:YucShoi卜wci.Doctor.Professor,Docloralsupervisor,DepartmentofRehabilitation,QiluHospitalofShandongUniversity.Ji'nan250012.ShandongProvince・Chinashouweiy@sdu.edu.cnReceived:2008-01-2
3、2Accepted:2OO8-O7-3()干细胞移植治疗脊髓损伤的进展崔贵祥仁,李义召2,岳寿伟IAdvancesinstemcelltransplantationforspinalcordinjuryCuiGui-xiang1*2,LiYi-zhao2,YueShou-wei1Abstract:Besidesneuralstemcells,bonemarroworotherderivedmesenchymalstemcells,olfactoryensheathingcells,embryonicstemcells,and
4、umbilicalcordbloodstemcells,theskinoradiposetissues・derivedstemcells,Schwanncells,glialcellsandfibroblastscanalsobetransplantedtotreatspinalcordinjury.Tracingstemcellsinvivoandanalysisbyultrastructure,immunohistochemistryandimagingrevealthattransplantedcellscanmigr
5、ateandgathertotheinjuredregions,survivewellanddifferentiateintoneuralprecursorsorneuralcells,astrocytes,andoligodendroglialcells,expressingspecialmarkers・Inaddilion.lhetransplantedcellscanintegratelothetissuesaroundthelesions,andreducethesizeofthecontusioncavity.Th
6、eaxonregeneratesandiscoveredbynewmyelinsheath.Thesensoryand/orlocomotorrecoveryisimproved・Neurotrophicfactorsplayanimportantroleintheculture,proliferationanddifferentiationofstemcells,andregenerationandrcmyclinationofncuritc・CuiGX,LiYZ,YueSW.Advancesinstemcelltrans
7、plantationforspinalcordinjuiy.ZhongguoZuzhiGongchengYaiijiuyuLinchuangKangfu2(X)8;12(47):9335-9338(0hina)[http://www.crter.cnhttp://en.zglckf.com]摘要：目前发现，除了神经干细胞、骨髓或其他來源的间充质干细胞、嗅神经勒细胞以及胚胎干细胞和脐血干细胞以外，皮肤来源.脂肪纽织来源的干细胞、许旺细胞、胶质细胞和成纤维细胞等均可用于脊髓损伤的细胞移植治疗。体内标记示踪以及超微结构、免疫组织化
8、学和彩像学等检查显示，移植后的干细胞在神经系统内可以迁移，在病变部位聚集.存活、分化成为神经前体细胞或神经细胞、星形胶质细胞和少突胶质细胞，分别表达具特征性标志物.并与周I韦I组织整合，轴索再生并有新的艇梢覆盖，使病变的瘓腔缩小，宿主的感觉/运动功能改善。神经营养因子在干细胞的培养.增殖、
