吸入糖皮质激素

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1、1Inhaledcorticosteroids:hazardouseffectsonvoice-anupdate.吸入糖皮质激素：有害影响语音更新。DepartmentofClinicalSurgery,UniversityofMassachusettsMedicalSchool,Worcester,Massachusetts,USA.singingsurgeon@comcast.net摘  要：Inhaledcorticosteroids(ICS)havebecometheprevalenttreatmentinasthmatics.Hazardstovoiceareunder-recogn

2、ized.Atotalof38patientswithvoicecomplaintsassociatedwiththeuseofICSwereassessedby79strobovideolaryngoscopy(SVL)examinations,24singleand14multipleSVL.Hoarsenessanddysphoniaweretheprimaryreasonsforreferral.TheICSinitiallyusedmostfrequentlywasAdvairDiskus(fluticasonepropionateandsalmeterol-inhalationpo

3、wder-[IP])in22patients,followedbyFlovent(fluticasonepropionateinhalationaerosol-pressurizedmetered-doseinhaler-[PMDI])in11.DurationofICSusagevariedfrom2weeksto4-5years.Higherdosageandfrequencyofuseexacerbatedproblems.Hazardstovoicepreviouslyunrecognizedbyreal-timeindirectmirrororfiberopticlaryngosco

4、pywereidentifiedbymeticulousattentiontoSVLabnormalities.Therewasessentiallynodifferenceinoccurrenceofabnormalitieswhetheranalyzedfromtheperspectiveoftheinitial38orall79examinations.Theseincludedabnormalmucosalwavesymmetry/periodicity(76-63%),phaseclosure(74-63%),glotticclosure(63-59%),mucosalwaveamp

5、litude/magnitude(50-35%),supraglottichyperactivity(39-25%),mucosalquality(34-34%),andglotticplane(10-5%).Candidiasisofthelarynxwasinfrequentlyobserved.FluticasoneICSwereacauseofsteroidinhalerlaryngitis,andthebesttreatmentwastheiravoidanceorcessation.FurtherprospectivestudiesideallymightincludeSVLdoc

6、umentedasapretherapybaselineandthenrepeatedineachICSpatientwhodevelopedhoarseness/dysphonia.参考中文摘要：吸入糖皮质激素（ICS）的流行，已成为治疗哮喘。危害声音受到公认。一共有38例语音投诉与使用ICS的是由79strobovideolaryngoscopy（SVL）考试，24日和14多个单SVL。声嘶和发音障碍是最主要的原因在于推介。ICS的最初最常使用的是Advair吸入（丙酸氟替卡松和沙美特罗吸入粉末[知识产权]）22例，其次是Flovent（替卡松吸入气雾剂加压计量吸入器[PMDI]）11。I

7、CS的使用期限从2个星期到4-5年。更高剂量和使用频率加剧的问参考中文标题：评价声门良性病变：刚性伸缩频闪与悬挂microlaryngoscopy。作者单位：DepartmentofSurgery,UniversityofWisconsinSchoolofMedicine,DivisionofOtolaryngology-HeadandNeckSurgery,UniversityofWiscons