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ID:46844161
大小:666.50 KB
页数:21页
时间:2019-11-28
《糖代谢3-单磷酸己糖支路05》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第四节单磷酸己糖支路hexosemonophosphateshunt为生物合成提供还原力(ProvidesNADPHforbiosynthesis)为核酸合成提供核糖(Producesribose-5-P)包括两个氧化步骤和五个非氧化步骤(Twooxidativeprocessesfollowedbyfivenon-oxidativesteps)主要存在于肝细胞和脂肪细胞的胞液中(Operatesmostlyincytoplasmofliverandadiposecells)磷酸戊糖途径PentosePhosphatePathway氧化步骤Oxidativ
2、eStepsofthePentosePhosphatePathway葡萄糖-6-磷酸脱氢酶(Glucose-6-PDehydrogenase)-Irreversible1ststep-highlyregulated!葡萄糖酸内酯酶(Gluconolactonase)Uncatalyzedreactionhappenstoo6-磷酸葡萄糖酸脱氢酶(6-PhosphogluconateDehydrogenase)Anoxidativedecarboxylation(inthatorder!)非氧化步骤TheNonoxidativeStepsFivesteps
3、,only4typesofreaction...磷酸戊糖异构酶(Phosphopentoseisomerase)-convertsketosetoaldose磷酸戊糖表异构酶(PhosphopentoseEpimerase)-epimerizesatC-3转酮醇酶(Transketolase)(TPP-dependent)-transferoftwo-carbonunits转醛醇酶(Transaldolase)(Schiffbasemechanism)-transfersathree-carbonunitTransaldolase磷酸戊糖途径的多样性1)B
4、oth(核糖-5-磷酸)ribose-5-PandNADPHareneeded2)Moreribose-5-PthanNADPHisneeded3)MoreNADPHthanribose-5-Pisneeded4)NADPHandATPareneeded,butribose-5-PisnotBoth(核糖-5-磷酸)ribose-5-PandNADPHareneeded2)Moreribose-5-PthanNADPHisneeded3)MoreNADPHthanribose-5-Pisneeded4)NADPHandATPareneeded,butrib
5、ose-5-Pisnot请列举两种与糖代谢有关的微生物发酵产品,并简述其代谢途径。糖酵解中生成的NADH有哪些方式被重新氧化?写出反应式。一分子乙酰-CoA彻底降解可生成多少ATP?说明产生ATP的步骤和方式。请总结磷酸戊糖途径的生物学意义。习题
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