门冬氨酸钾镁用于术中补钾的临床研究

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1、门冬氨酸钾镁用于术中补钾的临床研究【关键词】门冬氨酸钾镁【摘要】H的观察门冬氨酸钾镁的临床效果。方法选择ASAI〜II级全麻下行腹部手术病人60例，随机分成4组(n=15),病人入手术室后采静脉血检测钾、镁离子浓度及尿中钾离子浓度，开始全麻诱导。各组补钾液在40min内滴完，静点平衡液1500ml,在补钾后120min滴完。以用药前、用药后60min.120min为取时点监测参数。I组作对照，不补钾、镁;II组单纯补氯化钾;III组补氯化钾加硫酸镁;IV组补门冬氨酸钾镁。后3组补钾液中钾离子浓度及总

2、量相同，后2组补钾液中镁离子浓度及总量相同。结果用药前4组病人血淸钾、镁离子浓度无明显差异(P>0.05),用药后I组血清钾、镁离子浓度有不同程度降低;II组血淸钾浓度比I组升高明显(P<0.01),镁浓度降低，尿中钾浓度较高;III组血清钾浓度升高幅度略低于II组(P>0.05),镁浓度未降低，尿中钾浓度低于I【组;IV组血淸钾、镁浓度升高与III组差异无显著性(P>0.05),尿中钾浓度明显低于III组(P<0.01)o4组病人均未见明显副作用，ECG未见传导阻滞及高钾、高镂改变。结论静滴门冬氨

3、酸钾镁，由于氨基酸载体作川和镁离子的激活酶作丿IJ,使细胞内液钾离子浓度升高明显，冇利于细胞内外钾离子的平衡，限制尿液中钾离子的丢失，是一•种较理想的术中补钾方法。【关键词】门冬氨酸钾镁氯化钾硫酸镁术中补钾Clinicalobservationofpotassium-magnesium-aspartateinintraoperativesupplementingpotassiumWangLu,LiShujie,LiShumei,etal・DepartmentofAnesthesiology,739H

4、ospital,Shenyang110034.【Abstract]ObjectiveObservingtheeffectofpotassium-magnesium-aspartateinsupplementingpotassi-um.Methods60patientsinabdominaloperationunderASAI〜IIgeneralanesthesiawererandomlyselectedanddivided4groups(15patientsforeachgroup).Theconc

5、entrationsofpotassiumandmagnesiuminvenousbloodandpotassiuminurineweremeasuredbeforegeneralanesthesia^thengeneralanesthesiawasmade.Supplementingpotassi-umliquidofallgroupsweredrippedin40min.1500mlbalancedliquidwasdrippedbyveininl20minaftersupple-menting

6、potassium.Parametersweremonitoredat60min,120minbeforeandaftergivingpotassium-magnesium-as-partate.Group1wasascontrolgroupandonlydripped1500mlbalancedliquid,notgivenpotassiumandmagnesiumsulfate.Group2givenKC1only.Group3wasgivenpotassiumchlorideandmagnes

7、ium.Group4wasgivenpotassium-magnesium-aspartate.ConcentrationandamountofpotassiuminsupplementarypotassiumliquidforGroup2wasthesameasGroup3andGroup4.Concentrationandamountofmagnesiuminsupplementarypotassiumliquidforgroup3wasthesameasGroup4.ResuitsTherew

8、erenotsignificantdifferenceamong4groupsforserumpotassiumandmagnesiumbeforeusingmedicine(P>0.05)・ConcentrationofserumpotassiumandmagnesiumdescendedinGroup1afterusingbalanced1iquid.Concentrationofserumpotassiumincreased(P<0.01力serummagnes