门冬氨酸钾镁用于术中补钾的临床研究.doc

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1、门冬氨酸钾镁用于术中补钾的临床研究【关键词】门冬氨酸钾镁【摘耍】目的观察门冬氨酸钾镁的临床效果。方法选择ASAI〜II级全麻下行腹部手术病人60例，随机分成4组（n=15）,病人入手术室后采静脉血检测钾、镁离子浓度及尿中钾离子浓度，开始全麻诱导。各组补钾液在40min内滴完，静点平衡液1500ml,在补钾后120min滴完。以用药前、用药后60min>120min为取时点监测参数。I组作对照，不补钾、镁;II纽单纯补氯化钾;III组补氯化钾加硫酸镁;IV组补门冬氨酸钾镁。后3纽补钾液中钾离子浓度及总杲相同，后2纽补钾液屮镁离子浓度及总量相同。结果用药前4组

2、病人血清钾、镁离子浓度无明显差异（P>0.05）,用药后I纽血清钾、镁离子浓度有不同程度降低;II组血淸钾浓度比I纽•升高明显（PvO.01）,镁浓度降低，尿中钾浓度较高;【II纽血淸钾浓度升高幅度略低于II纽.（P>0.05）,镁浓度未降低，尿中钾浓度低于II纽;IV纽血清钾、镁浓度升高与III纽差异无显著性（P>0.05）,尿中钾浓度明显低于III组（PvO.01）。4组病人均未见明显副作用，ECG未见传导阻滞及高钾、高镁改变。结论静滴门冬氨酸钾镁，山于氨基酸载体作用和镁离子的激活酶作用，使细胞内液钾离子浓度升高明显，有利于细胞内外钾离子的平衡，限制尿

3、液中钾离子的丢失，是一•种较理想的术中补钾方法°【关键词】门冬氨酸钾镁氯化钾硫酸镁术中补钾Clinicalobservationofpotassium-magnesium-aspartateinintraoperativesupplementingpotassiumWangLu,LiShujie.LiShumei,etal.DepartmentofAnesthesiology,739HospitaLShenyang110034.【Abstract]ObjectiveObservingtheeffectofpotassium-magnesiuaspartat

4、einsupplementingpotassi-um.Methods60patientsinabdominaloperationunderASAI~IIgeneralanesthesiawererandomlyselectedanddivided4groups（15patientstoreachgroup）・Theconcentrationsofpotassiumandmagnesiuminvenousbloodandpotassiuminurineweremeasuredbeforegeneralanesthesia,thengeneralanesthe

5、siawasmade.Supplementingpotassi-umliquidofallgroupsweredrippedin40min」500mlbalancedliquidwasdrippedbyveininl20minaftersupple-mentingpotassium.Parametersweremonitoredat60min,120minbeforeandaftergivingpotassium-magnesium-as-partate.Group1wasascontrolgroupandonlydripped1500mlbalanced

6、liquid,notgivenpotassiumandmagnesiumsulfate.Group2givenKC1only.Group3wasgivenpotassiumchlorideandmagnesium.Group4wasgivenpotassium-magnesium-aspartate.ConcentrationandamountofpotassiuminsupplementarypotassiumliquidforGroup2wasthesameasGroup3andGroup4.Concentrationandamountofmagnes

7、iuminsupplementarypotassiumliquidforgroup3wasthesameasGroup4.ResultsTherewerenotsignificantdifferenceamong4groupstorserumpotassiumandmagnesiumbeforeusingmedicine（P>0.05）・ConcentrationofserumpotassiumandmagnesiumdescendedinGroupIafterusingbalancedliquid.Concentrationofserumpotassiu

8、mincreased（PvO.Ol）,serummagnesium