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1、特布他林联合布地奈德雾化吸入治疗支气管哮喘临床疗效［摘要］目的探讨特布他林联合布地奈德雾化吸入治疗支气管哮喘的疗效。方法将82例支气管哮喘患者随机分为治疗组和对照组，每组41例，对照组采用常规药物治疗，治疗组在常规药物治疗基础上应用特布他林联合布地奈德雾化吸入。比较两组患者治疗前后症状、体征消失时间及肺功能改善情况，并比较两组患者临床疗效。结果治疗后治疗组总有效率优于对照组(x2=4.2486,PvO.05)；治疗组主要症状和体征消失时间均明显少于对照组(P<0.05)；治疗后两组患者肺功能指标均显著改
2、善，治疗组改善情况优于对照组(P<0.05)o结论布地奈德联合特布他林雾化吸入能够快速缓解支气管哮喘患者症状和体征，改善肺功能，提高临床疗效，可在临床推广应用。［关键词］特布他林；布地奈德；支气管哮喘［中图分类号］R562.25［文献标识码］B［文章编号］1673-9701(2014)16-0058-03ClinicaleffectofterbutalinecombinedwithbudesonideaerosolinhalationintreatmentofbronchialasthmaYEChunx
3、ingZHUOSongmingMAZhenSUNJunshengSHENYanLINaDepartmentofRespiratory,ShenzhenCityLonggangCentralHospital,Guangdong,Shenzhen518000,China[Abstract]ObjectiveToinvestigatetheeffectofterbutalinecombinedwithbudesonideaerosolinhalationintreatmentofbronchialasthma
4、・Methods82patientswithbronchialasthmawererandomlydividedintotreatmentgroupandcontrolgroup,41caseswereineachgroup,thecontrolgroupweretreatedwithconventionaldrugs,thetreatmentgroupweretreatedwithterbutalinecombinedwithbudesonideaerosolinhalationbasedonconv
5、entionaltreatment.Comparesymptoms,signsdisappeartimeandlungfunctionimprovementofpatientsintwogroupsbeforeandaftertreatment,andcomparetheclinicalefficacyofthetwogroups・ResultsThetotalefficiencyaftertreatmentofthetreatmentgroupwasbetterthanthatofthecontrol
6、group(x2=4.2486,P<0.05)；thetimeofmainsymptomsandsignsdisappearinthetreatmentgroupweresignificantlylessthancontrolgroup(P<0.05)；Lungfunctionofpatientsintwogroupsaftertreatmentsignificantlyimproved,thetreatmentgroupimprovedbetterthanthecontrolgroup(P<0.05)
7、・ConclusionBudesonidecombinedwithterbutalineaerosolinhalationcanquicklyrelieveasthmasymptomsandsigns,anditcanimprovethelungfunctionandtheclinicalcurativeeffect,anditcanbepopularizedinclinicalapplication.[Keywords]Terbutaline；Budesonide；Bronchialasthma支气管
8、哮喘是一种呼吸道慢性变态反应性疾病，病理过程由肥大细胞、嗜酸性粒细胞和T细胞等多种炎性细胞和细胞因子共同参与[1],呼吸道的高反应性为本病的主要特征。哮喘以反复发作的喘息、呼吸困难、胸闷或咳嗽为主要临床表现，给患者的生活质量产生严重影响。糖皮质激素联合B2受体激动剂雾化吸入可有效缓解症状，持续性减少发作次数，改善患者肺功能，从而对哮喘起到有效治疗作用[2],本研究釆用特布他林联合布地奈德雾化吸入治疗支气管哮喘取得显著疗效，现报道如下。1资料
