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1、甲钻胺为何能治疗周围神经损伤?周围神经损伤，特别是挤压伤后，可采取的治疗措施包括基因治疗、细胞治疗、神经营养因子治疗等，但都存在一些不足，如现有载体的缺陷、外源性基因持续高表达、可能产生的高昂治疗费用、细胞来源、移植手段、远期疗效评价等。甲钻胺是一种含金属元素钻的维生素B12,是与神经系统功能相关的重要因子之一，临床上常用于促进周围神经功能的恢复，但治疗作用机制尚不清楚。来自中国无锡市第二人民医院甘霖等领导的团队发现，甲钻胺腹腔注射可改善坐骨神经夹伤小鼠坐骨神经功能，促进损伤侧神经组织牛长相关蛋白43及腰脊髓L4-L6节段背根神经节中神经营养因子的表达。文章全面评价了甲钻胺对小鼠坐骨神经损伤
2、后再生的促进作用，并探讨阐释了甲钻胺促近坐骨神经损伤修复可能的的分子机制。而甲钻胺可改善损伤周围神经有髓神经纤维的髓鞘厚度和靶肌细胞横截面积这一观点,将会对未来周围神经损伤的治疗有显著意义。该实验结果发表在《中国神经再生研究(英文版)》杂志2014年口月第22期。Article:"Restorativeeffectandmechanismofmecobalaminonsciaticnervecrushinjuryinmice,"byLinGan,MinquanQian,KeqinShi,GangChen,YanglinGu,WeiDu,GuoxingZhu(DepartmentofOrtho
3、pedics,WuxiNo.2People'sHospital,Wuxi,JiangsuProvinee,China)GanL,QianMQ,ShiKQ,ChenG,GuYL,DuW,ZhuGX.Restorativeeffectandmechanismofmecobalaminonsciaticnervecrushinjuryinmice・NeuralRegenRes.2014;9(22):1979-1984.欲获更多资讯：NeuralRegenResWhyismecobalamineffectiveforperipheralnerveinjury?SICENCE新闻发布作者：甘霖稿号：N
4、RR_D_14・00314Peripheralnerveinjury,especiallycompressioncanbetreatedbygenetherapy,celltherapy,andadministrationofneurotrophicfactors・However,thereareseveraldifficultieswiththeuseoftheseapproachesinhumans,includingfindinganappropriatedonor;continuedelevatedexpressionoftheexogenousgene,hightreatmentc
5、osts,transplantationchallenges,andaneedforIong-termefficacyevaluation.MecobalaminisaformofvitaminB12thatcontainscobalt.Itisanessentialvitaminfornervoussystemfunctioning.Itisoftenclinicallyusedtopromotetherecoveryofperipheralnervefunction.However,themolecularmechanismbywhichmecobalaminpromotesfuncti
6、onalnerverecoveryremainsunclear.TheteamledbyLinGan,WuxiNo.2People'sHospital,Chinafoundthatintraperitonealadministrationofmecobalaminimprovedthefunctionalrecoveryoftheinjuredsciaticnerve,andincreasedthemRNAexpressionofgrowthassociatedprotein43innervetissueipsilateraltotheinjury,andofneurotrophicfact
7、ors(nervegrowthfactor,braiderivednervegrowthfactorandciliaryneurotrophicfactor)intheL4-6dorsalrootganglia.AnarticlepublishedinNeuralRegenerationResearch(Vol.9,No.22,2014)evaluatedthepromotingeffectofmecobal
