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1、200例高压氧结合化疗治疗晚期乳腺癌临床疗效观察李宁：李启明；杨明；周宏图［汪波I(1.第三军医人学新桥医院，重庆400037;2.广西桂林帀解放军181医院,桂林541002;3.江苏大学附属医院，镇江212001;!.吉林省四平市中心医院，四平136000)摘要目的探讨高压氧结合化疗治疗晩期乳腺癌的临床疗效和毒副反应。方法将200例晚期乳腺癌病人分为A组和B组，每组各100例患者，A组接受高压氧+CAF方案治疗，B组接受单纯CAF方案治疗，均完成2-3周期的治疗，通过X线、B超、CT、骨扫描、血常规、肝肾功能及临床检查，
2、并对其进行疗效和毒副反应评价。结果A组与B组的总缓解率有明显差异,分别为79.00%、57.00%(/<0.05)。中位生存期A组较B长。毒副作用都能耐受,但A组毒副反应较B组轻，重度反应A组较B组少。结论高压氧结合化疗能较好地捉高治疗晩期乳腺癌疗效，并能冇效地降低化疗对机体的毒副作用，值得临床推广应用。关键词：晚期乳腺癌；高压氧；化疗；疗效Theclinicalcurativeeffectobservationon200CasesofintermediateandAdvancedBreastCancercancerwith
3、hyperbaricoxygenationtherapycombinedwithchemotherapyI」ning,LIQi-min,YANGming,ZHOUHong-tuWANbo.仃.HyperbaricOxygenTherapj^Center,XinqiaoHospital,theThirdMilitaryMedicalUniversity,Chongqing400037,China;2.The181thHospitalofPLA,Guei.lin541002;3.TheAffiliatedHospitalofJi
4、angsuUniversity,Zhenjiang212001,China;4・CentralHospitalofSiping,Siping136000,GilingChina)Abstract:ObjectiveToinvestigatetheclinicaltherapeuticeffectofintermediateandlatephaseBreastCancerwithhyperbaricoxygentherapycombinedwithchemotherapy.Methods200Casesofintermedia
5、teandAdvaneedBreastCancercancerweredividedintoAandBgroups.AgroupwastreatedbyhyperbaricoxygentherapycombinedwithCAFschemechemotherapy・BgroupwasdealwithCAFsetupchemotherapy.Allcasesofchemotherapyundertakes2・3periodicity.ThecurativeeffectobservatedbyX-ray,CT,andB-mode
6、ultrasonography.Bonescan,peripheralbloodcellcounting,Liverandrenalfunctionweretestedroutinely,inordertoevaluatedthesideeffectandtherapeuticresults・ResultsThetotalremissionrateofAandBgroupsgetdifferencesignificanUy.Agroup79.00%andBgroup57.00%(P<0.05)respectly.Agroup
7、isbetterthanBgroupinMedianSurvivalTime・AgroupgetbetterthanBgroupinsideeffectandsevereadversereaction・ConclusionsThegoupsofhyperbaricoxygentherapycombincdwithchemotherapygetbettortherapeuticeffectandlowersideeffectsthanthecontrolgroup.11istobeworthtogeneralization・K
8、eywords:AdvancedBreastCancer;hyperbaricoxygen;chemotherapy;curativeeffect乳腺癌是女性最常见的恶性肿瘤z-,II前认为它是-•种全身性疾病,它的发病率近年来逐渐上升，是危害妇女健康的第2位恶性肿瘤，而在人城市居第1位⑴
