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1、纳洛酮、依达拉奉与高压氧联用治疗急性一氧化碳中毒迟发型脑病的临床研究唐学军解放军第四五七医院神经内科，湖北武汉430012［摘要］目的探讨纳洛酮、依达拉奉与髙压氧联用治疗急性-•氧化碳中偉迟发型脑病的临床疗效。方法182例一讯化碳中毒迟发吃脑病(DEACMP)患者随机分为对照组和治疗组，对照组患者行高压氧、脑复新与纳洛酮治疗，治疗组患者行奇压氧、依达拉奉与纳洛酮治疗。比较两组患者的临床疗效、运动功能和生活满意度评分。结果治疗组的痊愈率明显高于对照组，无效率明显低于对照组，而总有效率明显高于对照组，治疗后两组患者BBS评分明显•比治疗前升高，而Barthel评分明显降低；治疗组BBS评分明
2、显高于对照组，而Barthel评分明显低于对照组，治疗组SF-36各项评分明显岛于对照纽。上述结果差异均具有统计学意义(P<0.05)o结论纳洛酮、依达拉奉与高斥氧联用治疗急性-氧化碳中毒迟发型脑病疗效显”，不良反应少，可明显改科患者的运动功能障碍和精神障碍，值得临床推广。［关键词］一氧化续中毒迟发型脑病；依达拉奉；纳洛酮；髙压氧［中图分类号］R595.1［文献标识码］A［文章编号］1673-7210(2012)05(3)-0046-03ClinicalresearchofcombinationofNaloxone,Edaravoneandhyperbaricoxygeninthetre
3、atmentofdelayedencephalopathyafteracutecarbonmonoxidepoisoningTANGXuejunDepartmentofNeurology,the457thPeople'sLiberationArmyHospital,HubeiProvince,Wuhan430012,China[Abstract]ObjectiveToresearchtheclinicaleffectofcombinationofNaloxone,Edaravoneandhyperbaricoxygeninthetreatmentofdelayedencephalopat
4、hyafteracutecarbonmonoxidepoisoning.Methods182DEACMPpatientswereran・domlydividedintocontrolgroupandtreatmentgroup.Thecontrolgroupweregivenhyperbaricoxygen,NaofuxinandNaloxonetreatment,whilethetherapygroupwereadministratedhyperbaricoxygen,EdaravoneandNaloxone.Clinicaleffi cacy,motorfunctionandlife
5、satisfactionscorewerecomparedbetweenthetwogroups.ResultsTherecoveryrateoftreat mentgroupwasobviouslyhigherthanthecontrolgroup,noefficiencywassignificantlylowerthanthecontrolgroup,andthetotalefficiencywasobviouslyhigherthanthecontrolgroup.AftertreatmentBBSscoreoftwogroupswassignificantlyelevated,a
6、ndBarthelscorewassignificantlyreduced;BBSscoresintreatmentgroupweresignificantlyhigherthanthoseinthecontrolgroup,whiletheBarthelscorewassignificantlylowerthanthatofthecontrolgroup,thescoreofSF-36oftreat mentgroupwashigherthanthatofcontrolgroup.Theseresultswerestatisticallysignificant(P<0.05).Conc
7、lusionCom・binationofNaloxone,EdaravoneandhyperbaricoxygentreatingwithDEACNPhascurativeeffect,lessadversereaction,anditcansignificantlyimprovepatientmovementdysfunctionandpsychiatricdisorders,whichisworththeclinicalprom
