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1、小剂量普蔡洛尔治疗婴幼儿血管瘤的临床观察小剂量普荼洛尔治疗婴幼儿血管瘤的临床观察[摘要]目的:探讨小剂量普蔡洛尔治疗婴幼儿血管瘤的疗效及安全性。方法:收集增生期婴幼儿血管瘤23例(男6例,女17例),口服普蔡洛尔0.5-0.75mg/(kg・d),疗程1〜9个月,并进行疗效评定和安全性评价。结果:疗效评定:优6例(26.1%),良9例(39.1%),中等8例(34.8%);不良反应包括:心率轻度减慢8例(34.78%),睡眠障碍2例(8.7%),腹泻1例(4.3%)。不良反应轻,均1周内自行消失;安全性评定:15例为安全,8例为比较安全。结论:小剂量普蔡洛尔治疗
2、婴幼儿血管瘤,疗效良好,不良反应轻,安全性较好。[关键词]血管瘤;婴幼儿;普蔡洛尔[中图分类号IR732.2[文献标识码]A[文章编号11008-6455(2011)10-1584-02Clinicalobservationsoninfantilehemangiomastreatedwithlow-dosepropranololFENGJin-yunl,RAOGuo~zhou2,PENGZhen-hui3(1.DepartmentofDermatology,TheChildrenHospitalofShenzhen,Shenzhen518026,Guangdon
3、g,China;2.MedicalScienceResearchCenter,StomatologicalHospital,XianJiaotongUniversity;3.DepartmentofDermatology,theSecondHospitalofXianJiaotongUniversity)Abstract:0bjectiveToexploretheefficacyandsafetyoflow-dosepropranololinthetreatmentofinfantilehemangiomas・MethodsAtotalof23infants(6
4、malesand17females)withproliferativehemangiomasweretreatedwithpropranolol.Propranololwasorallyadministeredat0.5to0.75mg/kg/day.Thetotaltimeoftherapywas1monthto9months・Theefficacyandsafetyofmedicationwasevaluatedafterfinishingtreatment・ResultsResponsetopropranololtherapywasexcellentin6
5、patients(26.1%),goodin9patients(39.1%),fairin8patients(34.8%)andnonepoor・Mildadverseeffectswerenotedin8patients(34.8%),includingheartrategentlyslowing(34.8%),mildsleepdisorder(8.7%)anddiarrhea(4.3%)・Theadverseeffectsdisappearedwithinoneweekoftheiroccurrence,needingnospecialhandling.S
6、afetyevaluationoftherapyshowedsafein15patients(65・2%),relativesafein8patients(34.8%).ConclusionsLow-dosepropranololiseffectiveandsafeinthetreatmentforinfantilehemangiomas,withonlylimitedandmildsideeffects・Keywords:hemangioma;Infant;Propranolol婴幼儿血管瘤(Infantilehemangiomas)是婴幼儿时期最常见的良性肿
7、瘤。多数学者认为,对增长较快或影响功能和容貌的血管瘤应进行积极的干预。现有治疗血管瘤的方法有时疗效不确切,且有一定的副作用。2008年,Leaute-Labreze等[1]首次发现普荼洛尔对血管瘤有显著的治疗效果,使得普蔡洛尔成为药物治疗血管瘤的•种新选择。另据报道⑵,与口种人相比,中国人对普荼洛尔的敏感性较高、耐受性较差;这提示在使用普蔡洛尔治疗中国婴幼儿血管瘤时,应该减少普蔡洛尔的使用剂量。为此,本研究采用小剂量普蔡洛尔,治疗较大面积及影响容貌和功能的增生期血管瘤,以观察小剂量普荼洛尔治疗增生期血管瘤的疗效及安全性。1资料和方法1.1增生期血管瘤的诊断:参照
8、相关文献[3-4],将同