口服普萘洛尔治疗40例面颈部婴幼儿血管瘤的临床观察

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1、口服普蔡洛尔治疗40例面颈部婴幼儿血管瘤的临床观察口服普蔡洛尔治疗40例面颈部婴幼儿血管瘤的临床观察［摘要］目的：评价普蔡洛尔口服治疗婴幼儿血管瘤的临床疗效及不良反应。方法:对40例而颈部血管瘤患儿进行口服普蔡洛尔治疗，并以32例强的松治疗的血管瘤患儿作对照。治疗组予口服普荼洛尔加g/(kg■d),分2次服用。住院治疗3〜4天，为安全起见,第1天服全量的1/4,第2天服全量的1/2,第3天服全量。若无异常就可出院，且出院后继续按原剂量服药。每2〜3周复诊1次，并观察瘤体的大小、质地、颜色，随访和同时针对药物的不良反应进

2、行处置；对照组采用口服强的松3mg/(kg・d),隔日1次，晨起时顿服，两组患者各自用药后，根据病变的生长、萎缩并稳定或服药时间满6个月为停药指征。按4级评分法(优、好、中、差)对近期疗效进行评价。结果：疗效统计，治疗组：优12例(30.00%),好21例(52.50%),中5例(12.50%),差2例(5.00%),有效率82.50%；对照组：优5例(15.62%),好9例(28.12%),中12例(37.50%),差6例(18.75%),有效率43.75%。治疗组与对照组的有效率比较差异有统计学意义(P<0.05)

3、o治疗组不良反应发生率7.5%,对照组为56.25%,两组比较差异有统计学意义(P<0.05)o结论：普蔡洛尔口服治疗婴幼儿血管瘤的方法有效，不良反应少，值得临床推广应用。［关键词］血管瘤；婴幼儿；普蔡洛尔；强的松［中图分类号］R739.5［文献标识码］A［文章编号11008-6455(2014)14-1177-04Clinicalobservationofpropranololtakenorallyto40casesofinfantilehaemangiomasZHANGLi,CHENYong,YIGuang-jia

4、o(DepartmentofOralandMaxillofacialSurgery,TheSecondPeople，sHospitalofYunnanProvince,Kunming650021,China)Abstract：ObjectiveToinvestigatetheclinicedefficacyandadverseeffectsofpropranololtakenorallyinfantilehaemangiomas・MethodsBetweenFebruary2010andFebruary2013,40i

5、nfantswithheamangiomaswereusedasstudygroupbyusingpropranolol.Atadoseof2.Omg/(kg・d),bydividinginto2timeswithcontinuousmedication.Thepatientswerehospitalizedfor3〜4days.Forsecurity,thefirstdayused1/4ofthefulldoes,theseconddayused1/2offulldoes,andthethirddayusedthef

6、ulldoes・Iftherewasnoabnormalphenomena,continuedmedicationwithformerdoesaftertheyleavedthehospital.Takeasubsequentvisitafter2~3weeks,observingandrecordingthechangesoftumorsize,textureandcolor,theadverseeffectsaftermedicationwereobservedandmanagedaccordinglyatareg

7、ularintervaL32infantswithheamangiomaswereusedascontrolgroupmaterialsbyusingprednisone.Atadoseof3mg/(kg・d),thenextdaybefore8am.Takenatadraught・Afterthetreatmentbetweenthesetwogroups,thewithdrawalindicationswerethegrowthoftumor,theshrinkandstabilizeoftumorortaking

8、timeto6months・Theshort-termresultswereevaluatedbyusinga4-pointscalesystem(excellent,good,moderate,poor)・ResultsIngroupofpropranplolorally.Theoverallresponseofexcellen