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1、［摘要］目的：探讨口服普蔡洛尔治疗婴幼儿血管瘤的临床疗效、安全性及方法。方法：共收治56例体表血管瘤患儿，完善检查后口服普蔡洛尔治疗,初始剂量为0.5mg/kg/d,分2次餐后服用，若患儿无不良反应，则每日增加0.2mg/kg至总量1.5mg/kg/d,维持治疗4个月后每日减少0.2mg/kg至停药，治疗结束半年后参照Achauer标准进行疗效评定。结果：其中1例服药不到1个月因岀现疲劳、乏力，家属放弃治疗，2例服药3个月后瘤体基本消退而停药，其余53例均维持服药4个月，治疗结束时，大部分血管瘤明显缩小，颜色变淡，甚至消退，停药6个月后评定疗效：I级2例（
2、含复发1例），II级6例（含复发5例），III级17例，IV级31例，停药后复发6例。结论:口服普蔡洛尔是治疗婴幼儿血管瘤有效方法之一，其疗效及安全性可能与剂量及用药方式有关。［关键词］血管瘤；血管性疾病；普荼洛尔［中图分类号1R732.2［文献标识码］A［文章编号］1008-6455（2014）17-1449-05ClinicalstudyonoralpropranololtherapyforinfantilehemangiomaslocatedinsuperficialbodyFUShi-zhang,HUANGHe-ping,HUANGLin-ling
3、(DepartmentofCosmeticandPlastic,JiangxiWomenandChildrenHealthCareHospital,Nanchang330006,Jiangxi,China)Abstract：ObjectiveToexploretheefficacy,safetyandappropriatemethodoforalpropranololtreatmentforinfantilehemangiomaslocatedinsuperficialbody・Methods56infantswithhemangiomasinsuperf
4、icialbodyweretreatedfromJanuary2010toJanuary2013,including17malesand39females,withagerangedfrom3to24months.Propranololwasadministeredorallytwiceadayaftermealtoallthecasesafterexamination,whichwasbegunwith0.5mg/kg/d,andwasadded0.2mg/kgeverydaytillitaddedupto1.5mg/kg/donlyifcomplica
5、tionswerenotoccurredinthecases,andwasdecreasedby0.2mg/kgeverydaytowithdrawlwhenwastakenatthisdosefor4months.ThetherapyeffectafterstoppingtreatmentforsixmonthswasevaluatedusingAchauersystem・Results53casestookpropranololfor4months,exceptthat1casegaveuptherapybecauseofobviousfatigued
6、uringthefirstmonthoftreatment,and2casesendedtreatmentastheyhadgottencuredalmostlyaftertakingpropranololfor3months.Mosthemangiomasdecreaseddistinctlyinsizeandcolor,andevensomedisappearedcompletelywhentreatmentfelldue.2caseswerescaleI(including1recurrenee),6caseswerescaleII(includin
7、g5recurrence)，17caseswerescalellland31caseswerescalelVaftersixmonthsofpropranololwithdrawal.ConclusionOralpropranololisoneofeffectivemethodsforinfantilehemangiomas，boththeefficacyandsafetyareprobablyrelativetoitsdoseandusage・Keywords：hemangioma；vasculardisease；propranolol自从2008年法国
8、医生Leaute-Labreze意外发现口服普蔡洛尔可促使婴幼儿血
