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1、[摘要]目的:探讨口服普蔡洛尔治疗婴幼儿血管瘤的临床疗效、安全性及方法。方法:共收治56例体表血管瘤患儿,完善检查后口服普蔡洛尔治疗,初始剂量为0.5mg/kg/d,分2次餐后服用,若患儿无不良反应,则每日增加0.2mg/kg至总量1.5mg/kg/d,维持治疗4个月后每日减少0.2mg/kg至停药,治疗结束半年后参照Achauer标准进行疗效评定。结果:其中1例服药不到1个月因岀现疲劳、乏力,家属放弃治疗,2例服药3个月后瘤体基本消退而停药,其余53例均维持服药4个月,治疗结束时,大部分血管瘤明显缩小,颜色变淡,甚至消退,停药6个月后评定疗效:I级2例(
2、含复发1例),II级6例(含复发5例),III级17例,IV级31例,停药后复发6例。结论:口服普蔡洛尔是治疗婴幼儿血管瘤有效方法之一,其疗效及安全性可能与剂量及用药方式有关。[关键词]血管瘤;血管性疾病;普荼洛尔[中图分类号1R732.2[文献标识码]A[文章编号]1008-6455(2014)17-1449-05ClinicalstudyonoralpropranololtherapyforinfantilehemangiomaslocatedinsuperficialbodyFUShi-zhang,HUANGHe-ping,HUANGLin-ling
3、(DepartmentofCosmeticandPlastic,JiangxiWomenandChildrenHealthCareHospital,Nanchang330006,Jiangxi,China)Abstract:ObjectiveToexploretheefficacy,safetyandappropriatemethodoforalpropranololtreatmentforinfantilehemangiomaslocatedinsuperficialbody・Methods56infantswithhemangiomasinsuperf
4、icialbodyweretreatedfromJanuary2010toJanuary2013,including17malesand39females,withagerangedfrom3to24months.Propranololwasadministeredorallytwiceadayaftermealtoallthecasesafterexamination,whichwasbegunwith0.5mg/kg/d,andwasadded0.2mg/kgeverydaytillitaddedupto1.5mg/kg/donlyifcomplica
5、tionswerenotoccurredinthecases,andwasdecreasedby0.2mg/kgeverydaytowithdrawlwhenwastakenatthisdosefor4months.ThetherapyeffectafterstoppingtreatmentforsixmonthswasevaluatedusingAchauersystem・Results53casestookpropranololfor4months,exceptthat1casegaveuptherapybecauseofobviousfatigued
6、uringthefirstmonthoftreatment,and2casesendedtreatmentastheyhadgottencuredalmostlyaftertakingpropranololfor3months.Mosthemangiomasdecreaseddistinctlyinsizeandcolor,andevensomedisappearedcompletelywhentreatmentfelldue.2caseswerescaleI(including1recurrenee),6caseswerescaleII(includin
7、g5recurrence),17caseswerescalellland31caseswerescalelVaftersixmonthsofpropranololwithdrawal.ConclusionOralpropranololisoneofeffectivemethodsforinfantilehemangiomas,boththeefficacyandsafetyareprobablyrelativetoitsdoseandusage・Keywords:hemangioma;vasculardisease;propranolol自从2008年法国
8、医生Leaute-Labreze意外发现口服普蔡洛尔可促使婴幼儿血