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1、前列腺癌患者骨代谢标志物的临床应用前列腺癌患者骨代谢标志物的临床应用1.新疆乌鲁木齐市友谊医院骨科,新疆乌鲁木齐830001;2.新疆医科大学第五附属医院肿瘤科,新疆乌鲁木齐830011❷【摘要】目的:了解特异骨代谢标志物骨钙素N端中分子(OCN-MID)、B-胶原特殊序列(B-CTx)在前列腺癌患者血清屮的含量变化,探讨0CN-MID和3-CTx检测的临床应用价值。方法:选取2004年10月〜2009年12月收治于我院的新诊断的前列腺癌患者125例,分为骨转移组55例及无转移组75例,无转移组为对照组,检
2、测其血清骨钙素N端中分子(OCN-MID)、B-胶原特殊序列(BCTx)、甲状旁腺激素(PTH)、碱性磷酸酶(ALP)、钙(Ca和磷(P)值。结果:⑴与对照组比较,骨转移组血清OCN-MID明显低于对照组(p<0.01),B-CTx含量高于对照组(P<0.01),而血清Ca、P、PTH以及ALP差异无显著性(P>0.01);(2)不同分期前列腺癌患者分析结果表明,分期越晚,OCN-MID水平越低,而B-CTx水平却升高。结论:OCN-MID和B-CTx反映骨形成和骨吸收情况,可以帮助临床了解前列腺癌骨损害的
3、程度和评价病情,具有良好的临床价值。❷【关键词】骨钙素N端屮分子;B-胶原特殊序列;骨代谢标志物;前列腺癌❷doi:10.3969/j.issn.1006-1959.2010.08.065文章编号:1006-1959(2010)-08-2044-02©DetectionandclinicalapplicationofbonemetabolicmarkersinProstateCancerpatientsLIGangl,HUANGGuo-fu21.Departmentoforthopedics,Friends
4、hipHospitalofXinjiang;2.DepartmentofTumorMedicaine,FifthAffiliatedHospitalofXinjiangMedicalUniversity,Urumqi,830011,China❷[Abstract]0bjective:ToinvestigatethevaluevariationofN-MIDosteoealcin>0-CrossLaPs(0-CTx)inserumofPatientswithProstateCancer(PC),andexpl
5、oretheirclinicalsignificance・Methods:Tocollect125ProstateCancerPatientsfromourhospitalatthetimefromAngust2004to2009.SerumN-MIDosteocalcin,3-CTx,alkalinephosphatase(ALP),calcium(Ca)andphosphonium(P)weremeasuredin125ProstateCancerpatients:BoneMetastasesgroup
6、andnonBoneMetastasesascontrols・Results:ComParedtocontrolgroup,thecontentofN-MIDosteoealeinwasobviouslylowerinserumofBoneMetastasesgroup,whilethecontentofB-CTxwasmuchhigher(P<0.01).TheserumALP,Ca,pconcentrationsweresimilarbetweenBoneMetastasespatientsandco
7、ntrols(P>0.01).ByanalysisingtheresultsoftheProstateCancerPatientsindifferentstages,laterthestagewasclassified,thelowerthelevelofN-MIDosteoealeinwas,butlevelofserum3-CTxwasmuchhigher.Conelusions:N~MIDand3-CTxarebrief,fast,validbonemetaboliemarkerstoreflectb
8、oneformationandboneresorption.TheycanaidtheclinicalutilitytocomprehendthedamageextentofpatientswithProstateCancerandtoestimatePathogeneticcondition.sotheyhaveimportantclinicalvalue・❷[Keywords]N-MIDosteoealein