资源描述：
《临床医学毕业论文补肾健脾化瘀法对围绝经期妇女血清NO和氧自由基影响的临床研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、补肾健脾化瘀法对围绝经期妇女血清NO和氧门由基影响的临床研究作者：李晓昊，邓伟民，张金玉，邵玉，黄伟毅【摘要】【H的】观察补肾健脾化瘀法对围绝经期妇女血清NO(—氧化氮)及氧自由基的影响。【方法】采用随机数字表按就诊先后顺序将患者随机单盲分为屮药组(188例)及西药组(189例)。中药组口服补肾壮骨冲剂(山茱萸、鹿角胶、龟板胶、肉桂、巴戟天、仙灵脾、茯苓、三棱、泽泻、水蛭、郁金、骨碎补、山药等)治疗，西药组采用雌激素替代疗法(口服倍美力和安宫黄体酮)，连续服药2年。于服药示1年和2年统计忠者的血清NO、超氧化物歧化酶(SOD)、丙二醛(MDA)的变化情况及症状计分。【
2、结果】最终完全接受2年治疗的屮药组有135例(占718%),西药组有93例(占492%)；治疗后1年和2年统计，两组的血清NO、SOD水平均升高、MDA水平均降低(与治疗前比较，P<005),但组间比较，差异均无显著性意义(P>005)；在症状评分方面，两组治疗后总计分均比治疗前减少(P<005或P<001),组间比较，中药组比西药纟R更低(P<001)；治疗期内两组均未观察到明就毒副作用。【结论】补肾健脾化瘀法中药治疗围绝经期妇女，对纠匸体内NO、氧自由基等指标紊乱的作用与雌激素替代疗法和当，并较西药能更好地改善患者症状。【关键词】更年期；补肾；健脾；祛瘀；一氧化氮
3、/血液；活性氧/血液[Objective]Toobservetheinfluenceofkidneytonifying,spleenstrengtheningandbloodstasisremovingtherapyonserumnitricoxide(NO)andoxygenderivedfreeradicals(OFR)inpcrimcnopausal(PM)females.【Methods]PMfemaleswererandomizedintotwogroups：groupA(n=188)receivedBushenZhuangguGranules(mainly
4、composedofFructusCorni.CollaCornusCervi,CarapaxetPlastrumTestudinis,CortexCinnamomi,RadixMorindaeOfficinalis,HerbaEpimcdii,Poria,RhizomaSparganii.RhizomaAlismatis,ctc.),andgroupBreceivedhormonereplacementtherapy(oraluseofpremarinandprogesterone).Thepatientsreceivedthetreatmentfor2years.
5、SerumlevelsofNO,superoxidedismustase(SOD)andmalondialdehyde(MDA)weredetectedandsymptomswerescoredafter1yeartreatmentandafter2yeartreatment.【Results]Onehundredandthirtyfive(718%)patientsingroupAand93(492%)patientsingroupBfinished2yeartreatment.After1yeartreatmentandafter2yeartreatment,se
6、rumlevelsofNO,SODandMDAdecreasedinthetwogroups(P<005ascomparedwiththosebeforetreatment),andthedifferencewasinsignificantbetweenthetwogroups(P>005);symptomscoresdecreasedinthetwogroups(P<005orP<001ascomparedwiththosebeforetreatment),andthescoreswereloweringroupAthanthoseingroupB(P<001).N
7、oobvioustoxicandsideeffectswereobservedinthetwogroupsduringthetreatmen匸[Conclusion]Theeffectofkidneytonifying,spleenstrengtheningandbloodstasisremovingtherapyonregulatingtheserumlevelsofNOandOFRissimilartohormonereplacementtherapy,anditseffectonrelievingsymptomsisbetterthanthat
