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1、个体化治疗狼疮性肾炎23例临床分析［摘要］目的结合患者狼疮活动程度采取个体化治疗，评价使用坏磷酰胺、糖皮质激素治疗狼疮性肾炎的临床效果与不良反应。方法方便抽取该院2013年4月一2014年4月收治的狼疮性肾炎患者23例作为该次研究对象，依据患者狼疮活动程度不同将其分为轻度活动组(5例)、中度活动组(8例)、重度活动组(10例)等3个小组，分别予以患者泼尼松片、环磷酰胺治疗，观察各组患者的实验室指标与不良反应。结果3组患者接受个体化治疗后，其中有18例(7&2%)患者临床指标得到显著改善,不良反应明显
2、减轻。3组该次治疗总有效率为78.2%；治疗后3组患者24h尿蛋白、C3(g/L)、C4(g/L)>SCr(umol/L)等指标均有所改善,強异有统计学意义(P〈0.05)。结论感染、白细胞下降、肝功能受损等并发症是狼疮性肾炎治疗过程中的常见并发症，临床治疗屮需结合患者的实际病情采取个体化治疗，降低并发症发生率，减轻治疗中患者的不良反应。［关键词］狼疮性肾炎；环磷酰胺；临床效果［中图分类号］R59［文献标识码］A［文章编号］1674-0742(2016)10(a)-0063-03Individual
3、izedTreatmentof23PatientswithLupusNephritisClinicalAnalysisHUYi-yangDepartmentofRenalMedicine,Quan^houFirstHospitai,FujianProvince,Quanzhou,FujianProvince,362000China[Abstract]ObjectiveToevaluatetheclinicaleffectandadversereactionoflupusnephritistreate
4、dwithcyclophosphamideandglucocorticoidsincombinationwiththedegreeoflupusactivityinpatientswithindividualizedtreatment.MethodsConvenientselection23caseswereselectedinourhospitalfromApril2013toApril2014inpatientswithlupusnephritisastheresearchobject,acco
5、rdingtothedifferentdegreeoflupusactivityinpatientswithwillthepointstoamildactivitygroup(5cases),moderateactivitygroup(8cases)andseveregroup(10cases)andotherthreegroups,whichweretreatedwithprednisonetablets,cyclophosphamidetreatment,observationandadvers
6、ereactionoflaboratoryindexofpatientsineachgroup.ResultsThreegroupsofpatientsafterindividualtreatment,including18cases(78・2%)patientsclinicalindicatorsweresignificantlyimproved,theadversereactionwassignificantlyreduced.Threegroupsofthetreatmentoftotalef
7、fectiveratewas78.2%.Aftertreatment,thethreegroupsofpatients，24hurinaryprotein,(g/L)ofC3andC4(g/L),SCR(umol/L)andotherindicatorswereimproved,andthediffereneeisstatisticallysignificant(P<0.05)•ConclusionInfection,thedecreaseofwhitebloodcells,liverfunctio
8、ndamageandothercomplicationsiscommoncomplicationoflupusnephritistreatmentprocessandclinicaltreatmentforpatientswithactualconditiontakeindividualizedtreatment,reducetheincidenceofcomplications,reduceadversereactioninthetreatmentofpatient
