补肾健脾法治疗轻度认知功能障碍的临床研究

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1、目的：观察自拟方益源复智饮治疗轻度认知功能障碍的临床疗效，并从中I矢学角度探讨其病因病机。方法：参考目前国际公认的轻度认知功能障碍诊断标准，将符合纳入标准的轻度认知功能障碍患者62例，采用随机对照分组，分为治疗组（30例）和对照组（32例）。治疗照组服用“益源复智饮S对照组服用长春胺缓释胶囊（奥勃兰）。3个月为一个疗程。观察两组患者用药前后简易智能状态检查量表（MMSE）积分，蒙特利尔认知功能量表（MoCA）积分，中医临床症状积分的变化情况。结果：治疗组与对照组治疗前后在MMSE量表积分、MoCA量表积分及中医临床症状积分差

2、异有统计学意义（Pv0.05）；两组治疗前后差值比较在MMSE量表分值，MoCA量表分值上无统计学意义（P>0.05）,但中医临床症状积分差值比较，有统计学意义（Pv0.05）；依据中医临床症状疗效评定标准，治疗组与对照组经统计学检验，两组中医临床症状疗效差异具有统计学意义（Pv0.05）。结论：中药汤剂“益源复智饮”能改善MCI患者神经心理学量表积分，中医临床症状，对延缓轻度认知功能障碍的进展有一定的改善作用。关键词轻度认知功能障碍益源复智饮脾肾两虚ClinicalStudyonTreatmentofMildCogniti

3、veImpairmentbyBushenjianpiSpecialyt:InternalMedicineofTCM-ClinicalstudyonNerveSystemDiseaseAuthor:LidingdingTutor:Prof.SunlijunAbstractObjective:Toinvestigatetheclinicalefficacyofyiyuanfuzhiself^treatmenttomildcognitiveimpairmentsandfromthetraditionalmedicinepointo

4、fviewresearchitsetiologyofdisease.Methods：Accordingtotheintemationllyrecognizeddiagnosticcriterionofmildcognitiveimpairment,selected62casesofpatientswithMCI,randomizedgrouping,dividedintotreatmentgroup(n=30)andcontrolgroup(n=32).3OcasesintreatedgrouptakeYiyuanfuzhi

5、self^treatment;32casesincontrolgrouptakeBrovincamine.Patientswillbeobservedbeforeandafterthescalemini-mentalstateexamination(MMSE),TheMontrealCognitiveAssessment(MoCA),thesymptomsoftraditionalChinesemedicine(TCM)after3monthscourseoftreatmentoResults：Inthetreatmentg

6、roupandthecontrolgroupbeforeandaftertreatmentinMMSEscores,MoCAscores,thescoresofsymptomsofTCMonthedifferencebetweenstatisticalsignificancc(p<0.05)；ComparsionofthetwogroupbeforeandaftertreatmentinMMSEscores^MoCAscores,thedifferenceWasnotstatisticallysignificantbysta

7、tisticaltests(P>O.O5),butinChinesemedicinesyndromesintegrationonthemarginofcomparisontherearestatisticallysignificant(P<0.05)；Syndromebasisofevaluationstandards.thetreatmentgroupandthecontrolgroupweretestedbytwogroupsofChinesestatisticallysignificantdifference(p<0.

8、05).Conclusion：yiyuanfuzhiself^treamenthavecertainclinicalefficacyinthetreatmentofmildcognitiveimpairmentwithspleenandkidneydificiencyandcanimpro