高强度窄谱蓝光治疗面部寻常性痤疮临床观察

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1、高强度窄谱蓝光治疗面部寻常性瘗疮临床观察［摘要］目的：观察高强度窄谱蓝光治疗面部寻常性瘗疮的疗效。方法：应用波长为405〜420nm的高强度窄谱蓝光治疗93例面部寻常性痙疮患者，每周2次，共治疗8次。计数患者炎性皮损（丘疹、脓疱、结节和囊肿）、非炎性皮损（粉刺）及皮损总数来计算改善率；观察患者治疗前后皮肤黑素指数、红斑指数、皮脂分泌及角质层含水量的变化情况。结果：治疗结束时，总有效率为82.80%0非炎性及炎性皮损平均改善率分别为51.67%和6&90%；患者面部红斑指数及皮脂分泌显著降低，而黑素指数及角质层含水量与治疗前比较无显著变化。随访3个月，总有效率与治疗结束时相比差异无统计学意义

2、。结论：高强度窄谱蓝光治疗面部寻常性瘗疮疗效显著，且可以减轻皮肤红斑、减少皮脂分泌。［关键词］蓝光；寻常性痙疮；黑素指数；红斑指数；皮脂［中图分类号1R758.73［文献标识码］A［文章编号］1008-6455（2007）10-1400-04Treatmentoffacialacnevulgarisbyahigh-intensity,narrow-bandbluelightsourceLIUMeil,LIYuan-hong1,WUYanl,D0NGGuang-hui2,XUYuan-yuan1,HEChun-di1,CHENHong-Duol(1.DepartmentofDermatolo

3、gyofNO.1Hospital,KeyLaboratoryofImmunodermatologyofMinistryofHea1th,ChinaMedicalUniversity,Shenyang110001,Liaoning,China；2.DepartmentofBiostatistics,ChinaMedicalUniversity)Abstract:ObjectiveToobservetheefficacyofphototherapywithahigh-intensity,narrow-bandbluelightsourceinpatientswithfacialacnevulg

4、aris・MethodsNinty-threepatientswithfacialacnevulgarisweretreatedwiththe405-420nmbluelight,twiceweeklyfor4weeks.Thenumberofinflammatorylesions(papules,pustules,nodulesandcysts),non-inflammatorylesions(comedones)andthetotalnumberwerecountedtoevaluatetheimprovement・Thechangesofskinmelaninindex,erythe

5、maindex,sebumsecretionrate,corneumwatercontentwereobservedbeforeandaftertreatment.ResultsAfterthetreatment,82・80%ofthepatientsgotmorethan60%improvement・Meonpercentageimprovementsafterthefinaltreatmentinnon-inflammatoryandinflammatorylesionswere51.67%and68.90%,respectively.Atthe3-monthfollow-upvisi

6、t,theglobalimprovementdidnotchangealot.Erythemaindex,sebumsecretiondecreasedsignificantlyafterthefinaltreatment.However,melaninindexandcorneumwotercontentremainedatthelevelbeforethetreatment・ConclusionBluelighttreatmentiseffectiveforpatientswithfacialacnevulgaris・Itcanalsorelievetheskinerythemaand

7、reducesebumsecretion.Keywords:bluelight；acnevulgaris；melaninindex；erythemaindex；sebum痙疮是一种累及毛囊皮脂腺的慢性炎症性皮肤病，好发于皮脂溢出部位，青少年发病率高。如果不进行恰当治疗，严重者会遗留永久性瘢痕，影响患者的外貌美观及生活质量。由于系统应用维甲酸或抗生素治疗会发生一系列不良反应，加之随着痙疮丙酸杆菌对抗生素耐药性的增加，为寻常