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1、益心舒治疗冠心病慢性心力衰竭临床观察作者：吴刚勇，宗刚军，陈景开，陈满清，夏阳单位：解放军第101医院心内科，江苏无锡市214044【摘要】目的：评价益心舒胶囊对冠心病慢性心力衰竭(CHF)患者的临床疗效。方法：选择80例冠心病CHF患者，随机分为対照组(40例)，益心舒组(40例，常规治疗的基础上加服益心舒胶囊1.2g,3次/d),服用6个月后观察两组治疗前后NYHA心功能、左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、6min步行试验、24h心肌缺血发作次数以及再住院率和病死率。结果:益心舒组总有效
2、率(95%)优于对照组(65%),NYHA心功能、LVEF、LVESD、6min步行试验、24h心肌缺血发作次数较对照组有显著改善(P<0.05〜&比0.01),益心舒组的再住院率较对照组明显降低(15%:40%,P<0.05),但病死率两组无显著差异，未发现与药物相关的不良反应。结论：在常规治疗冠心病心衰的基础上加用益心舒，可进一步提高疗效，改善心功能。【关键词】益心舒;心力衰竭，充血性;心功能EffectsofYixinshucapsuleinpatientswithcoronaryheartdiseasecomplicatedc
3、hroniccongestiveheartfailureWUGangyong,ZONGGangjun,CHENJingkai,CHENManqing,XIAYang,WANGXiao,ZHANGLiAbstract：Objective:ToinvestigatetheeffectsofYixinshucapsuleinpatientswithcoronaryheartdiseasecomplicatedchroniccongestiveheartfailure(CHF).Methods:Eightycaseswererandomlydivided
4、intocontrolgroup(n=40)andYixinshugroup(n=40).Incontrolgroup,patientsreceivedroutinetherapy.InYixinshugroup,patientsreceivedYixinshucapsule1.2g,3times/dabovebasedofroutinetherapyforsixmonths.Heartfunction,Leftventricularejectingfraction(LVEF),leftventricularendsystolicdiameter
5、(LVESD),leftventricularenddiastolicdiameter(LVEDD),6-minutewalkingtestand24-hcardiacischemicnumberweremeasuredbeforeandaftertreatment.Inaddition,rehospitalizationandmortalitywereobserved.Results:Thetotaleffectiverate(95%)inYixinshugroupsurpassedtocontrolgroup(65%,P<0.05).A
6、ftertreatmenttheLVEF,LVESD,6-minwalkingtestand24-hcardiacischemicnumberinYixinshugi'uopsignificantlyimproved,andmorethanthoseofcontrolgroup(P<0・05);therehospitalizationrateofYixinshugroupobviouslydecreasedthanthatofcontrolgroup(15%:40%,P<0・05)・AdverseeffectinYixinshugro
7、upwasnotfound.Conclusion:AddingYixinshubasedontheroutinetherapycanimprovethetherapeuticeffectandtheheartfunctioninCHDpatientswithCHF.Keywords：Yixinshu;Heaitfailure,congestive;Heartfunction冠心病心肌长期缺血、缺氧导致收缩功能下降，迓而可发展为心力衰竭。利尿剂、血管紧张素转化酶抑制剂及β受体阻滞剂是H前临床常川的治疗心力衰竭川药。随看祖国医学的发扬光大和
8、屮药制作工艺的进展，中成药的应用H益受到亜视。益心舒胶囊主要由生晒参、丹参、麦冬、五味子、黄罠、川芦、山楂等7味中药组成，具有益气复脉、
