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《视黄醇结合蛋白、胱抑素C及β2微球蛋白联检对2型糖尿病早期肾损害的诊断价值》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、视黄醇结合蛋白、胱抑素C及B2微球蛋白联检对2型糖尿病早期肾损害的诊断价值【摘要】目的：探讨视黄醇结合蛋白(RBP).胱抑素C(CysC)及B2微球蛋白(B2-MG)联检对2型糖尿病(T2DM)早期肾损害的诊断价值。方法：将选取的125例T2DM患者根据尿白蛋白排泄率分成止常蛋白尿组(62例)、微量蛋白尿组(63例)，另选健康体检人员45例做对照组,所冇受检者血清RBP采用免疫透射比浊法检测，CysC、B2-MG采用颗粒增强免疫透射比浊法检测。结果：微量蛋白尿组血清RBP、CysC、B2TIG、Urea及Crea含量及阳性率较另外
2、两组高(P<0.05)；正常蛋白尿组RBP、CysC及B2-MG含量及阳性率较对照组高(P<0.05)；两试验组RBP、CysC、B2-MG阳性率较Urea或Crea高(P<0.05)；两试验组RBP与CysC联检的阳性率较单项指标高,RBP、CysC与B2-MG三项联检时阳性率较RBP与CysC两项联检高(P〈0.05)。结论：RBP、CysC及B2-MG可作为T2DM早期肾损伤诊断的有价值的指标，联合检测意义更大。【关键词】视黄醇结合蛋白；胱抑素C；02微球蛋白；2型糖尿病；早期肾损害中图分类号R587.2文献标识码A文章编号
3、1674-6805(2014)24-0041-03DiagnosticValueofRetinolBindingProtein,CystatinCandB2MicroglobulininType2DiabetesMellitusEarlyRenalDamage/SUWen-lang,LIUJing.//ChineseandForeignMedicalResearch,2014,12(24)：41-43【Abstract]Objective：Tostudythediagnosticvalueofsrumretinolbindingp
4、rotein(RBP),cystatinC(CysC)andP2microglobulin(P2-MG)inearlyrenaldamage.Method：125caseofT2DMwereselected.Theurinaryalbuminexcretionrate(UAER)of62PatientswithT2DMwaslessthan20ug/minwasnormalalbuminuriagroup,theUAERof63patientswithT2DMwassituatedbetween20ug/minand200ug/m
5、inwasmicroalbuminuriagroup.45casesofhealthypeoplewascontrolgroup・RBPwastestedbytheimmuneturbidimetricmethod,CysCand02~MGweretestbyparticleenhancedimmunoturbidimetricassay.Result：ThecontentandthepositiverateofRBP,CysC,B2-MG、ureaandcreatinineinmicroalbuminuriagroupwereh
6、igherthanothertwogroups(P<0.05)・TheContentandthepositiverateofRBP,CysC,B2-MGinnormalalbuminuriagroupwerehigherthancontrolgroup(P<0.05).ThepositiverateofRBPandCysCwashigherthanRBPorCysC(P<0.05)・ThepositiverateofRBP,CysCor32-MGinthetwoexperimentalgroupwerehigherthanUrea
7、orCrea(P〈0.05)•ThepositiverateofRBP,CysCandB2-MGinthetwoexperimentalgroupwerehigherthanRBPandCysC(P<0.05)・Conclusion：RBP,CysCand32-MGcanbeusedasmarkerindiagnosistype2diabetesmellitusearlyrenaldamage,theclinicalvalueofcombineddetectionisgreater.【Keywords]Retinolbinding
8、protein；CystatinC；02microglobulin；Type2diabetesmellitus；EarlyrenaldamageFirst-authorsaddress：HuaihuaSecondPeople'sHospital,I
