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1、(1,3)—B—D葡聚糖检测于患儿侵袭性肺部真菌感染临床诊断中的应用价值［摘要］目的讨论于儿童肺部侵袭性真菌感染的临床诊断中血浆(1，3)-P-D葡聚糖检测及支气管肺泡灌洗液的应用价值。方法整群选取2014年3月一2015年4月间于该院住院治疗的肺部侵蚀性真菌感染患儿33例，作为实验组，选取同期单纯肺炎患儿31例及非肺炎患儿29例记为肺炎组及非肺炎组。将所冇选屮患儿的支气管肺泡灌洗液(1,3)-B-D葡聚糖检测(G试验)结果进行统计，并与血浆G试验对比，讨论两种方法使用价值。结果实验组BALFG试验结果(283.1
2、2±123・5)pg/mL与血浆G试验结果(99・3±23・2)pg/mL对比优势明显差异有统计学意义(t=3.542,P二0.014)；肺炎组BALFG试验结果(17.4±6.2)pg/mL与血浆G试验结果(11.2±3.8)pg/mL相比,差异无统计学意义(t二-3.708,P二0・803)；非感染组BALFG试验结果(17.4土6.2)与血浆G试验结果(5・6±3.2)相比，差异无统计学意义(t=-2.568,P=0.712)；实验组结果明显高于其它两组，差异有统计学意义(t二4.125,P二0.011)；3
3、组血浆G试验结果相比，试验组明显高于其他两组，差异有统计学意义(t=3.578,P二0.013)o结论BALFG试验及血浆G试验均可对肺部侵袭性真菌感染做出明确诊断，且与血浆G试验相比，BALFG试验丁肺部侵袭性真菌感染的诊断中更早、更准确，临床价值更高。［关键词］真菌性；血浆；尊聚糖；支气管肺泡［中图分类号］R726［文献标识码］A［文章编号］1674-0742(2015)11(b)-0177-02［Abstract］ObjectiveTodiscusstheapplicationvalueofdetection
4、(1,3)~P-D-glucaninplasmaandthatinbronchoalveolarlavagefluid(BALF)intheclinicaldiagnosisofchildrenwithinvasivepulmonaryfungalinfection.Methods33childrensufferingfrominvasivepulmonaryfungalinfectionhospitalizedinthishospitalfromMarch2014andApril2015wereincludeda
5、ndassignedtotheexperimentalgroup.Other31childrenwithsimplepneumoniawhoweretreatedinthishospitalinthesameperiodandweremarkedasthepneumoniagroupand29non-pneumoniachildrenwhoweretreatedinthishospitalandweremarkedasthenon-pneumoniagroupwereassignedtothecontrolgrou
6、p.Theresultsofdetectionof(1,3)-3-D-glucan(Gtest)inBALFofal1thechildrenincludedinstudywererecordedandcomparedwithplasma(1,3)-P-D-glucandetection(Gtest)results.Thevalueofthetwomethodsintheclinicaldiagnosisofchildrenwithinvasivepulmonaryfungalinfectionwasdiscusse
7、d.ResultsIntheexperimentalgroup,theresultofBALFGtestwassuperiortothethatofplasmaGtest［(283.12±123.5)pg/mLvs(99.3±23.2)pg/mL］,andthedifferencewasstatisticallysignificant,(t=3.542,P二0.014)；inthepneumoniagroup,nostatisticallysignificantdiffereneecanbefoundbetween
8、theresultofBALFGtestandthatofplasmaGtestwhichwas(17.4±6.2)pg/mLvs(11.2±3.8)pg/mL,t二-3.708,P二0.803)；inthenon-pneumoniagroup,nostatisticallysignificantdifferencecanbefoundbetweenther
