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1、网织红细胞相关参数测定在贫血初筛诊断中的意义作者:黄华,陈林兴,尹俊,曾哲【摘要】冃的:评价网织红细胞(RET相关参数测定在贫血初筛诊断屮的意义。方法:应用贝克曼库尔特LH.750自动血液分析仪对患者的RET百分比(RET%、RET绝对值(RET#、未成熟RET指数(IRF、平均RET体积(MRV、平均球形红细胞体积(MSCV和强光散射RET百分比和绝对值(HLR%和HLR#进行检测。结果:溶血性贫血RET%、RET#、IRF、MRV、MSCV、HLR%、HLR#与正常对照组比显著增高(P<0.01;缺铁性贫血R
2、ET%、RET#、IRF、HLR%、HLR#与正常对照组比稍高,但无统计学意义,而MRV、MSCV与正常对照组比有统计学意义(P<0.01;再生障碍性贫血RET%、RET#、IRF、HLR%、HLR#与正常对照组比明显降低(P<0.01,而MRV、MSCV与正常对照组比无统计学意义;急性白血病RET相关参数与正常对照组比无统计学意义。结论:RET相关参数测定可以更细微、全面地描述RET的成熟度,从而更好地评价骨髓造血的功能,对贫血初诊有重要的实用价值。【关键词】网织红细胞相关参数;LH.750型自动血液分析
3、仪;贫血;诊断[Abstract]Objective:Toevaluatethesignificanceofreticulocyte(RET_relatedparametersdeterminationinanemiapreliminarydiagnosis・Methods:RETrelatedparameters(reticulocytepercentage(RET%,RETcount(RET#,immatureRETfraction(IRF,meanRETvolume(MRV,meanspheredcel1volu
4、me(MSCV,high1ightscatterRETpercentageandabsolutevalue(HLR%andHLRttweredeterminedusingLH_750automaticbloodanalyzerinpatientswithanemia・Results:RET%,RET#,IRF,MRV,MSCV,HLR%andHLR#inpatientssufferingfromhemolyticanemia(HAwereobviouslyhigherthanthoseofnormalcontrolgr
5、oup(P<0.01,whileRET%,RET#,TRF,HLR%andHLR#inpatientswithirondeficiencyanemia(IDAwereslightlyhigherthanthoseofnormalcontrolgroup,buttherewerenosignificantdifferencesamongthem,however,thestatisticalsignificanceexistedbetweenpatientssufferingfromIDAandnonnalcontr
6、olgroupinMRVandMSCV(P<0.01.RET%,RET#,IRF,HLR%andHLR#inpatientswithaplasticanemia(AAweremarkedlylowerthanthoseofnormalcontrolgroup(P<0.01,whiletherewasnostatisticalsignificemceinMRVandMSCV,TherewasnosignificanceinRET_relatedparametersbetweenpatientssuffe_ri
7、ngfromacuteleukemiaandnormalcontrolgroup.Conclusion:RET_relatedparametersareabletodescribeoverallthematureofRETindetail,andtoevaluatehematopoiesisofthebonemarrowandtopresentanimportantvalueinanemiapreliminarydiagnosis.[KeyWords]reticulocyte_relatedparameter,LH75
8、0automaticbloodanalyzer,anemia,diagnosis血细胞分析仪的普遍应用,扩大了血液学常规检测的范畴,所提供的各种参数已日益受到重视。近年来,许多高中档常规血液分析仪都配有自动网织红细胞(RET分析功能,即口动吸样、处理和分析RET,消除了手工涂片、染色和不同技师操作导致的结果偏差,使实验流程更标准化