宣威地区肺癌患者血清和肺组织硒水平研究

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1、DOI:103779/j.issn.1009-3419.2011.01.08•临床研究•宣威地区肺癌患者血清和肺组织硒水平研究周炭.黄云超王竹叶联华候文俊杨凯云【摘要】背景与目的宣威杲我国肺癌高发区，有研究发现肿瘤的死亡率与硒的地理分布及摄入就呈负相关，肺癌死广率与血硒水平呈负相关，本研究通过检测宣威肺癌患者的血清硒含就和肺组织硒水平，以初步探讨宣威地区肺癌高发与硒的关系，方法取120例宣威女性的血清，其中试验组为60例师癌患者・对照纽为60例非肿瘤IE呼吸道疾病人殊，测定梵血清硒水平。术中取60例肺癌患者的肺癌组织、癌旁帅组织和正常肺组

2、织・其中31例来自于宣威地区，29例来自于非宣威地区，分析癌组织、癌旁组织及正常组织的硒含MeiflL清和组织硒均采用荧光法进行测定c结果宜威地区女性肺癌患者血清硒含量为(55.22±13.34)pg/L,低于对照组(60.33±13.82)pg儿(PvO.OS)0宣威地区肺癌组织硒含最为(0.105±0.034)pg/g,低于正常肺组织(0.140±0.048)pg/g(P<0.05)。宣威地区和非宣威地区肺癌组织、癌旁肺组织和正席肺组织间硒水平无统计学差异。腺癌和鳞癌、不同分期的肺癌组织、癌旁肺组织和正常肺组织之间的硒水平均无统计学差

3、异。结论宣威地区肺癌的发生纭低血硒状态有关，肺组织细胞低硒可能是导致癌变的潜在危险因素。【关键词】肺肿瘤；硒；宣威【中图分类号】R734.2SerumandLungTissueSeleniumMeasurementsinSubjectswithLungCancerfromXuanwei,ChinaLanZHOU：YunchaoHUANG1,ZhuWANG2,LianhuaYE*,WcnjunHOU：KaiyunYANG*"TheThirdAffiliatedHospitalofKunmingMedicalUniversity,Yunnan

4、TumorHospital,Kunming650118,China;"instituteofNutritionandFoodSafety,ChineseCenterJorDiseaseControlandPrevention,Beijing1000S0,China;^XuanweiPeoplesHospitalofYunnanProvince,Xuanwei6SS400,ChinaCorrespondingauthor：YunchaoHUANG,E-tnail:huangych2001(3fyahoo.com.cn【Abstract]Ba

5、ckgroundandobjectiveXuanweiisanareaofthehighestincidenceandmortalitywithlungcancerinChina.TheaimofthisstudyistodetermineserumseleniumconcentrationsinlungcancerpatientsfromXuanweiaswellasseleniumlevelsofcanceroustissues,cancer-adjacentpulmonarytissues,andnormalpulmonarylun

6、gtissuesfromlungcancerpatients,andtherelationshipbetweenseleniumandthehighincidenceoflungcancerinXuanwei.MethodsOnehundredandtwentyfemaleadultsfromXuanweiwereenrolledinthestudy(60lungcancerpatientsand60withnon-tumorandnon・respi・ratorydiseases,respectively)andbloodsamplesw

7、erecollected・Sixtyfreshcanceroustissuesandtheiradjacentaswellasnormaltissueswerecollected(31samplesfromlungcancerpatientslivinginXuanweiformorethan2yearsand29frompatientsinotherregionsofYunnanProvinceoutsideofXuanwei,respectively).Serumandtissueseleniumconcentrationswere

8、assayedusingafluorometricmethod・ResultsWomenwithlungcancerhadameanserumseleniumvalue(55.22pg/L±1