药合试题库按鸢药合试题库及答案aspanclass=

《药合试题库按鸢药合试题库及答案aspanclass=》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、药物合成反应习题参考答案（一）第一章卤化反应1.写出下列反应的主要产物（或试剂）①CH3OC拠亠HIb也HkCOQH%

2、、、、H、HICCI4.2-5uC'/—c'計H②niBinBlnn.AT0，X0'HIjOOHIj；szA*□□UeifM9HIjOOHkHIjOCNIBISLDIMISO*AH203GH3H一Hololo■2eCH3；OHH3C-6一C—CH2Blrich3；hHlzIC'Fl^COOAgNBIS/DIMISO'CH3：01H3C-C—6—C'H2Blnch3：FI3COOTOSiM岂%NIBSTHIFI0^0OAc«0“2HCH3NaOOH3.CH30'HCH3

3、CH2OHCH3II2・写出下列反应的可能产物①OHbWlc人nMn,wHIBhtOOX-HI3p-U-UHI2ON►(OHl3)2OC'HI2CHI3；+(iC'HI3)2OHIC'HIC'H3；+(C'HI3)3CC'HI2Blnc，hi3：BlnBlnHI3C'CHjCC14refCOOCH3NIBS/(6HsCC>)2O2COOC'HI^HICOOC'HI^bH3+IoO'O'II“2：Bl「匕KCIOs：H2O'11hBI「i11%H3C-C-O-OH2CH3；►H3o-C-C-OH2OH3^BlrHI2O-C'-Q-CHI2CHI340'-50X光照3Z3OCOCH3;_严

4、％%“CHsOOOqHH/C2H5H3C;Q2H5：H3C'xCHQ2H5尸*十oooch33.写出下列反应的主要试剂及条件①R0r^/170-1800'C{iC'H2OH)4►C{OH20ri)4.②SOC'l^/ref..HOOO(CH2)4COO'H—►CICO{CHz)4COOIIPIHOHCOCH3C'llSOOIMret耐CH2COCH30「QWAl^/LTA/CC^/ref..——1o几HgO川2仏AgNO)厂H2,rKOHA,W第二章姪化反应1.完成下列反应①HIO'HO/―'XOH®—HI^COOOOHINlaOHIAhi3ooooOOHI3HIOHIOCOCH.:K

5、^CO3HOcochi3HH3C-C-C'H2；OH60為HH3O-C'-OH2OOH36h③rOH3O'HH2SO4H—H3C1—O’-p'H?’OOH3OHOHsONa”VHOIVISSOq8595P⑥H3C-N—(CH2)5VIIO'NIOZ0(iOOOC2H5)2ar(iC'H2)5.Sri+0H2('COOO2H5)2GWNaC3H5OHNHZoh2oh0Rlamey-N加热nhch2LDA/CH3OCH2CH2OCH3・40~0°C,酮过量2.完成下列反应过程oII::^qC>HlbONIaN-CH[COOCtzHJ2a6C池OH11O0IIoN-0(COOC屮血gCHzCO

6、OC^MbJ0Oii、C'NaNI-C(COOC^Hb)zoIIoHOI.HQ.PlyOHyDOOHOlCHzGOOQHI如T5OTSg)”rt2NI-C{COOC'2Hb：)26H2COOC乂Hl»②HC二O+ch3nihi2O'IICbH5CHzNH2:©HSPHCOI4AC^H5CHzNHPI(OCl；;H5)^H2C=C-CH2:Bln/.53%NaOH曰(m-C'4.H9.)4HSO4.④O'。赳refCQOHjJsO'IIQHQHzNPKQCb®;CHzOH二CHzCbH5CHzNH-HClCHZCH=CHZQHbM卿OQHsbHzC'=oh3c-ohz6CH2OI>・O'1

7、•完成下列反应h3co+CH3COCIoch3AICI3Toch3o2ncich2conhN迥JNN甲ch3DCCTHFcich2conhCONHs、COOHn-nHN严CH3(CH2)5COCIAICI3CICH2CH2CI,0°Cch3+c6h5n-choPOCI390-95°CHNHCOCHCI2c-c-ch2oh+CH3(CH2)16COCIPy>OHHC6H6HNHCOCHCI2厂〒H-CH2OCO(CH2)16CH302N—OHHooIIIIch3c一c—c—oc2h5+h21.完成下列合成路线①(NaOH/QHsBr)oc2H5讣_sCH3ch3CO2N3COCIoc2H5

8、0CONHOC2H5OCH3CO?Na以苯和丁二酸肝为起始原料合成四氢荼1.①第四章缩合反应0H改错（只能改动一处）㊉㊀Ph3P—CHCH3oIIch3ch2ch2cch3+CH3COOC2H5塑型里C3H7、CHCOOC2H5CH3CH2CH2COCH2COCH3(C2H5)2OBrCH2CO2C2H5pr^CHCOOC2H52.完成下列反应式①CH2O(excess)Ca(°H)2>(HOH2CCICH2CO2CH30CH3ON