臭氧治疗外阴阴道假丝酵母菌病的临床研究

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1、臭氧治疗外阴阴道假丝酵母菌病的临床研究沈慧敏杨越波黄敏李小毛刘晓霞李卉张宇【摘要】目的评价臭氧治疗外阴阴道假丝酵母菌病的有效性和安全性。方法采用随机对照、开放设计，入选外阴阴道假丝酵母菌病患者72例，其中试验组36例接受臭氧治疗，对照组36例接受达克宁栓治疗，于治疗前、治疗结束后第3天观察临床症状及体征，并进行阴道分泌物病原学检查。结果治疗结束后第3天，试验组和对照组的痊愈率分别为5&3%和61.1%，有效率分别为83.3%和8&9%,症状平均缓解时间分别为2.58d和2.36d,假丝酵母菌阴转率分别为94.4%和100%。2组之间比较差异均无统计学意义(P>0.05)o72例病例中无不

2、良事件与严重不良事件发生。结论臭氧治疗外阴阴道假丝酵母菌病安全、有效。【关键词】臭氧;硝酸咪康哩栓汐卜阴阴道假丝酵母菌病AClinicalTrialofOzoneinTheTreatmentofVulvovaginalCandidiasisSHENHui-min,YANGYue-bo,HUANGakDepartmentofObstetricandGynecology,TheThirdAJJiliatedHospital,SUNYat-senUniversity,Guangzhou510630,China[Abstract]ObjectiveToevaluatetheefficacyan

3、dsafetyofozoneinthetreatmentofvulvovaginalcandidiasis.MethodsArandomized,controlled?openclinicaltrialincluding72casessufferedvulvovaginalcandi・diasiswasconducted,36casesintrialgroupweregivenozonetherapyand36casesincontrolgroupweregivenmiconazolenitratesuppositories.3daysaftertheendoftreatment,Co

4、mparedthechangeofclinicalsymptomsandsignstheresultofBVblueexaminationbetweentrialgroupandcontrolgroup.Results3daysaftertheendoftreatment,thecurerateswere5&3%intrialgroupand61.1%incontrolgroupTtheefficacyrateswere83.3%intrialgroupand88.9%incontrolgroup,theaverageperiodsofsymptomrelaxingwere2.58day

5、sintrialgroupand2.36daysincontrolgroup.Therewerenosignificantdifferencesbetweenthesetwogroups(P>0.05)•Theeradicatedratesofpathogenwere94.4%intrialgroupand100%incontrolgroup-Therewerenosignificantdifferencesbetweenthesetwogroupsineradicatedratesofpathogen(P>0.05).Therewerenoadverseventsandseverea

6、dverseeventshappenedinallthese72cases.ConclusionOzoneiseffectiveandsafeinthetreatmentofvulvovaginalcandidiasis.[Keywords]Ozone；Miconazolenitratesuppositories;Vulvovaginalcandidiasis1.1病例选择我院妇产科门诊外阴阴道假丝酵母菌病患外阴阴道假丝酵母菌病(vulvovaginalcandidiasis,VVC)也称外阴阴道假丝酵母菌病，是由不同假丝酵母菌(主要是白念珠菌)感染所致的外阴阴道炎症。为常见的妇女外阴阴

7、道炎症。据报道，约75%的妇女一生中至少患过1次VVC,5%的患者可反复发作，给广大妇女带来了巨大的生理和心理上的痛苦[b2]o因此如何治疗VVC—直是广大临床医生和妇女最关心的冋题之臭氧是一种高效、快速的消毒灭菌剂，具有高效消毒、强氧化和催化的功能，应用领域广泛⑶，但应用在治疗妇女生殖道炎症还是首次。本研究采用深圳市汇源田实业发展有限公司生产的臭氧妇科治疗系统HYS-2000治疗女性外阴阴道假丝酵母菌病,评价臭氧治疗外阴阴道假丝酵