胞磷胆碱配合遮盖治疗大龄弱视76例

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1、胞磷胆碱配合遮盖治疗大龄弱视76例【关键词】弱视/治疗关键词:胞昔二磷酸胆碱;弱视/治疗;视力，次正常摘耍：0的观察胞磷胆碱配合遮盖治疗大龄弱视患者的远期疗效.方法弱视患者76例，年龄12〜26（平均16.6±3.3）岁，接受1〜3个疗程的胞二磷胆碱治疗（体质量<；40kg,500mg・d-l,体质量240kg,1000mg・d-l）,每个疗程15d,随访3〜9mo•所有患者均先进行配镜矫正•对双眼视力相差超过两行（以国际标准视力表计）的患者，连续遮盖20d后，间断遮盖每周6d,3mo为一疗程•对双眼视力相当的远视患者配合双色光闪烁弱视治

2、疗仪治疗，双眼各15min・d-l.结果经1〜3个疗程后,80（71%）只眼视力提高在2行以上，其中36只眼（32%）提高在4行以上•停药5wk后视力均有不同程度降低，但遮盖及再次用药后仍能继续提高•坚持治疗的患者视力有波动，但趋势向好;优势眼视力与弱视眼的视力均可提高;视力25.0者视力仍可提高；大剂量组疗效显著•结论胞磷胆碱治疗大龄弱视，其疗效显著，无明显副作用.Keywords:cytidinediphosphatecholine;amblyopia/therapy;vision,subnormalAbstract:AIMToobservethefu

3、rthereffectsofciticolineinjectioncombincdwithocclusionthcrapyandothcrmcthodsonamblyopiapatientsolderthanl2years・METH0DS76amblyopiapatients(agedl2to26,average16・6+3・3)weregivenl〜3coursesofciticolineinjection(500mg・d-Iforpatientweight&11;40kg,1000mg・:d-lforpatientswithweight2

4、40kg),onecoursewa.sl5days,andfollowedupfor3〜9months・Allpatientsweregivenspectaclecorrectionatthefirstvisit.Forpatientswhosevisualacuity(VA)differencesbetweentwoeyesweremorethantwolines(accordingtoin-ternationalvisualacuitytestchart),thebetterseeingeyewasgivenocclusion6d・wkTafterco

5、mpleteocclusionfor20days.Two-color-shiningtherapeuticapparatuswereusedbypatientsforl5min・d-lwhosetwoeyesVAweresomewhatequal,15dayswasonecourse・RESULTSAfterl~3coursestreatment,80eyes(71%)obtained^2-linesVAim-provement,and36eyes(32%)obtained三4TinesVAen-hancement.VAwoulddropafterdrug

6、injectionwasstoppedfor5wk,buttheVAcouldbeenhancedifocclusionanddruginjectionweregivenagain.VAhadsomevariationiftreat-mentswerecontinued,butthetendencywastobetteref-fects・TheVAofbetterseeingeyesandamblyopiaeyescouldenhanceatthesametime・EyeswithbetterVA25.Ocouldalsobeimproved.Largedosegrou

7、pscouldgetmoresignifi-canteffects.CONCLUSIONTheeffectsofciticolineontreatingamblyopiapatientsolderthanl2weresignificant・Repeatedinjectionhasnosignificantsideeffect・0引言胞磷胆碱（Citicoline,CDP-choline）是一种神经科常用纟勺，近年来有报道对大龄弱视有效[1,2],但疗效不够稳定，我们选择可以接受遮盖、闪烁治疗的人龄弱视患者，并观察胞磷胆碱配合遮盖、双色光闪