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1、利培酮联合丙戊酸钠用于躁狂发作急性期治疗的临床研究【摘要】目的研究利培酮联合丙戊酸钠用于躁狂发作急性期治疗的安全性和有效性。方法97例躁狂发作急性期患者作为研究对象，随机分为试验组和对照组。试验组采用丙戊酸钠联合利培酮治疗，对照组采用丙戊酸钠治疗，观察6周，通过Bech-Rafaelsen躁狂量表评价有效性，并观察用药安全性。结果两组患者均顺利治疗，无一例脱落。治疗后6周，试验组临床治疗总有效率X87.8%,与对照组的85.4%比较，差异无统计学意义。治疗前两组BRMS评分比较差异无统计学意义。两组治疗后1、2、4、
2、6周末BRMS评分均逐渐降低，均低于治疗前。研究组治疗后1、2、4周末BRMS评分低于对照组，差异有统计学意义;两组治疗后6周末BRMS评分比较差异无统计学意义。两组患者不良反应主要为轻度和中度，可耐受，经过相应处理后不良反应缓解，试验组不良反应发生率为24.5%,与对照组的22.9%比较，差异无统计学意义。结论治疗急性躁狂症患者应用利培酮联合丙戊酸钠，能够缩短起效时间，安全有效。【关键词】躁狂发作；利培酮；疗效；安全性DOI：10.14163/j.cnki.ll-5547/r.2017.16.018Clinical
3、researchofrisperidonecombinedwithsodiumvalproateinthetreatmentofacuteperiodofmanicepisodeQINQiu-hong,JIANGTao.BeijingHuairouAnjiaHospital,Beijing101408,China【Abstract】ObjectiveToresearchsafetyandeffectivenessbyrisperidonecombinedwithsodiumvalproateinthetreatmen
4、tofacuteperiodofmanicepisode・MethodsAtotalof97patientswithacuteperiodofmanicepisodeasstudysubjectswererandomlydividedintoexperimentalgroupandcontrolgroup.Theexperimentalgroupreceivedrisperidonecombinedwithsodiumvalproatefortreatment,andthecontrolgroupreceivedso
5、diumvalproatefortreatment.After6-weekobservation,Bech-Rafaelsenmaniaratingscalewasusedtoevaluateeffectinessinpatients,andtheirmedicationsafetywasobserved・ResultsBothgroupsreceivedsuccessfultreatment,withoutanyfall-offcase.In6weeksaftertreatment,theexperimentalg
6、rouphadtotaleffectiverateinclinicaltreatmentas87.8%,whichwas85.4%inthecontrolgroup,andtheirdifferencehadnostatisticalsignificance・TherewasnostatisticallysignificantdifferenceofBRMSscorebetweenthetwogroupbeforetreatment・Attheendof1,2,4,6weeksintreatment,bothgrou
7、pshadgraduallylowerBRMSscoresthanthosebeforetreatment・TheexperimentalgrouphadalllowerBRMSscoreattheendofL2,4weeksintreatmentthanthecontrolgroup,andthedifferencehadstatisticalsignificance・ThedifferenceofBRMSscoreattheendof6weeksintreatmentbetweenthetwogroupshadn
8、ostatisticalsignificance・Bothgroupsshowedtolerablemildandmoderateadversereactions?whichwererelievedaftercorrespondingtreatment.Theexperimentalgrouphadincidenceofadversereact
