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1、布拉氏酵母菌治疗小儿急性腹泻病临床探作者：吉大章，邹商群，袁梁玉【摘要】目的：评估布拉氏酵母菌散剂治疗小儿急性腹泻病的临床疗效。方法：以我院2008年3月〜6月收治的92例小儿急性腹泻病患儿为研究对象，随机分成两组各46例。两组均予补液、蒙脱石散剂口服、抗生素治疗，治疗组加服布拉氏酵母菌散剂连续治疗至出院，对92例患儿资料进行数据分析。结果：两组总有效率比较差异有统计学意义(x2=4.84,P<；0.05)o腹泻平均持续时间对照组为(6.54±1.74)d,治疗组为(5.72±1.67)d(t=2.30,P<；0.05),两组比较差异有统计学意义；服药第4d治疗组日平均大便
2、次数(3.13±0.95)次，对照组(3.74±0.91)次(t=3.14,P<；0.01),服药第7d治疗组日平均大便次数(1.74±0.93)次，对照组(2.24±0.95)次(t=2.55,P<0.05),两组比较差异均有统计学意义；治疗组按给药治疗时机进行分层分析，比较第4d和第7d大便次数(t分别为3.90、3.71,P均<；0.01),差异有统计学意义。结论：布拉氏酵母菌可缩短小儿急性腹泻的持续时间，促进患儿恢复，患儿在腹泻发生48h内早期给予布拉氏酵母菌治疗效果更佳。【关键词】布拉氏酵母菌小儿急性腹泻微生态制[Abstract]Objective：Toe
3、valuatetheefficacyoftheprobioticyeastSaccharomycesboulardii(S.boulardii)intreatmentofchildrenwithacutediarrhea.Methods：Inaperiodofthreemonths(fromMarch2008toJune2008),92hospitalizedchildrensufferingfromacutediarrhea,agedfrom2monthsto7years,wereincludedinarandomizedplacebocontrolledtrialevaluat
4、ingtheefficacyofS・boulardiiadministeredfullperiodinhospital,with46childreninthecontrolledgroupreceivingconventionaltreatment(ORS,oralmontmorillonite,antibioticsifnecessary),other46childrenintheS.boulardiigroupreceivingS.boulardiiplusconventionaltherapies・ResuIts：TheefficacyintheS.boulardiigrou
5、pwasstatisticallysignificantlyhigherthancontrolledgroup(x2=4.84,P&It；0.05),themeandiarrheadurationwas6.54±1.74daysinthecontrolledgroupand5.72+1.67daysintheS.boulardiigroup(t=2.30,P<；0.05).Onthe4thday,thepatientsintheS.boulardiigrouppassed3.13±0.95stools/dayversus3.74±0・91stools/dayinthecontr
6、olledgroup(t=3.14,P<；0.01)・Onthe7thday,thepatientsintheS.boulardiigrouppassed1.74±0.93stools/dayversus2.24±0.95stools/dayincontrolledgroup(t=2.55,P<；0.05).Astatisticallysignificantdiffereneewasobservedinthenumberofstoolsonthe4thand7thdayfavouringthesubgroupthatreceivedearlytreatment(within
7、thefirst48hoftheonsetofdiarrhea)(t=3.90,3.71,P<；0.01).Conclusions：S.boulardiiasanadjuvanttoORSinhospitalsinchildrenwithmildormoderateacutediarrheaiseffectiveintreatmentofacutediarrhea,anditdecreasedthedurationofdiarrhea,acceleratedrec
