布拉氏酵母菌治疗小儿急性腹泻病的临床研究.doc

《布拉氏酵母菌治疗小儿急性腹泻病的临床研究.doc》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、布拉氏酵母菌治疗小儿急性腹泻病的临床研究作者：吉大章，邹商群，袁梁玉【摘要】　　目的：评估布拉氏酵母菌散剂治疗小儿急性腹泻病的临床疗效。方法：以我院2008年3月～6月收治的92例小儿急性腹泻病患儿为研究对象，随机分成两组各46例。两组均予补液、蒙脱石散剂口服、抗生素治疗，治疗组加服布拉氏酵母菌散剂连续治疗至出院，对92例患儿资料进行数据分析。结果：两组总有效率比较差异有统计学意义（χ2=4.84，P<0.05）。腹泻平均持续时间对照组为(6.54±1.74)d，治疗组为(5.72±1.67)d（t=2.30，P<0.05），两组比较差异有统

2、计学意义；服药第4d治疗组日平均大便次数（3.13±0.95）次，对照组（3.74±0.91）次（t＝3.14，P<0.01），服药第7d治疗组日平均大便次数（1.74±0.93）次，对照组（2.24±0.95）次（t=2.55，P<0.05），两组比较差异均有统计学意义；治疗组按给药治疗时机进行分层分析，比较第4d和第7d大便次数（t分别为3.90、3.71，P均<0.01），差异有统计学意义。结论：布拉氏酵母菌可缩短小儿急性腹泻的持续时间，促进患儿恢复，患儿在腹泻发生48h内早期给予布拉氏酵母菌治疗效果更佳。【关键词】布拉氏酵母菌小

3、儿急性腹泻微生态制　　［Abstract］Objective:ToevaluatetheefficacyoftheprobioticyeastSaccharomycesboulardii(S.boulardii)intreatmentofchildrenwithacutediarrhea.Methods:Inaperiodofthreemonths(fromMarch2008toJune2008),92hospitalizedchildrensufferingfromacutediarrhea,agedfrom2monthsto7years,werein

4、cludedinarandomizedplacebocontrolledtrialevaluatingtheefficacyofS.boulardiiadministeredfullperiodinhospital,with46childreninthecontrolledgroupreceivingconventionaltreatment(ORS,oralmontmorillonite,antibioticsifnecessary),other46childrenintheS.boulardiigroupreceivingS.boulardiipl

5、usconventionaltherapies.Results:TheefficacyintheS.boulardiigroupwasstatisticallysignificantlyhigherthancontrolledgroup(χ2=4.84,P<0.05),themeandiarrheadurationwas6.54±1.74daysinthecontrolledgroupand5.72±1.67daysintheS.boulardiigroup(t=2.30,P<0.05).Onthe4thday,thepatientsinth

6、eS.boulardiigrouppassed3.13±0.95stools/dayversus3.74±0.91stools/dayinthecontrolledgroup(t＝3.14,P<0.01).Onthe7thday,thepatientsintheS.boulardiigrouppassed1.74±0.93stools/dayversus2.24±0.95stools/dayincontrolledgroup(t=2.55,P<0.05).Astatisticallysignificantdifferencewasobserv

7、edinthenumberofstoolsonthe4thand7thdayfavouringthesubgroupthatreceivedearlytreatment(withinthefirst48hoftheonsetof5diarrhea)(t=3.90,3.71,P<0.01).Conclusions:S.boulardiiasanadjuvanttoORSinhospitalsinchildrenwithmildormoderateacutediarrheaiseffectiveintreatmentofacutediarrhea,an

8、ditdecreasedthedurationofdiarrhea,accele