【毕业设计-医学论文】急性白血病骨髓mri定性和定量诊断价值

《【毕业设计-医学论文】急性白血病骨髓mri定性和定量诊断价值》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、急性白血病骨髓MRI定性和定量诊断价值摘要目的：通过观察急性口血病治疗前后骨髓的MR1表现和T1及对比度噪声比(CNR)的测定，对照临床、病理资料，探讨急性口血病骨髓MR1定性和定量诊断价值。材料与方法：选样经临床确诊为急性口血病的患者38例，缓解组25例，对照组35例进行MR1检查及T1值和对比度噪声比(CNR)的测定。结果：急性口血病T1W1:治疗前组38例，腰紙椎、骼骨及股骨近段均表现为信号降低；化疗缓解组25例表现为不同程度的信号增高。T2W1：38例治疗前组和25例化疗后组各椎体、骼骨、股骨上段呈等信号。外周血B%、骨髓B%、腰椎T1值、腰椎/皮下脂肪CNR、

2、股骨骨髄/皮下脂肪CNR丁•急性白血病治疗前组与正常对照组、治疗前组少缓解组间的差异均有显著性(P0.05),不同细胞类型间的差异无显著性(P>0.05)。腰椎T1值于不同性别、年龄组间的差异无显著性(P>0.05)o治疗前组骨髓B%与腰椎T1值、与腰椎/皮下脂肪CNR,外周血B%与腰椎T1值、与腰椎/皮下脂肪CNR及腰椎T1值与腰椎/皮下脂肪CNR之间成直线相关(P关键词：急性口血病磁共振成像(MR1)诊断治疗TheValeofMRIinacuteleukemianaturallyandquantitatively[Abstract]objectiveToevalua

3、teMRIdiagnosisofbonenarrowinacuteleukemiabyobservingMRIappearaneoandcalculatingT1value,CNR(ratioofcontrast/noise)inpatientsbeforeandafterchemothrapy,contrastingtomaterialsinclinicandpathology.MaterialsandmethodsThirty-eightpatients,withacuteleukemiawereexamined.Twenty-fivepatientsserveda

4、sremissiongroup・Ascontrolgroup,35healthyvolunleerswereperformedMRexaminationwithidenticalmethods.SerialMRstudiesineludeobservationofMRIcharacterandmeasurementofT1valueandCNRinallpatients.ResultOfall38casesofacuteleukemiaatthetimeofdiagnosiscomparewithcontrolgroup:HypointensesignalinT1WIb

5、ywell-distributewerefoundinlumbosacralvertebral,iliac,andfemurapproaching・IsointensesignalinT2WIwasfoundinallcaseswedone.ThesignalintensityinT1W1tendedtonormalinail25remissioncasesofacuteleukemia・IsointensesignalalsofoundinT2W1inremissioncases.ThedifferenccofT1valueinlumber,CNRinlumber/s

6、ubcutarioousfatandfemur/subcutaneousfat,B%inbloodandmarrowweresignificant(P0.05)betweengroupsofcontrolandremissiorbandcellulalityamongALL,AML,ALL+AML.PositivelinearcorrelationwasfoundamongT1valueinlumberandB%inblood,T1valueinlumberandB%inmarrow,CNRinlumber/subcutaneousfatandB%inblood,CNR

7、inlumber/subcutaneousfatandB%inmarrow,T1valueinlumberandCNRinlumbcr/subcutarwousfat.TherewerestatisticSignificantamongthem(P[Keywords]acuteleukemia;Magneticresonanccimaging(MRI);diagnosis;chemothyrapy.既往，急性白血病定性及定量的检查方法为骨傩穿刺涂片或活检，为冇创伤性的检查。自从磁共振成像仪（MRT）问世并于1980年开始应用于临床以后，由