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1、医学论文.急性白血病骨fMRI定性和定量诊断价值摘要口的：通过观察急性白血病治疗前后骨髓的MRI表现和T1及对比度噪声比（CNR）的测定，对照临床、病理资料，探讨急性口血病骨髓MRI定性和定量诊断价值。材料与方法：选择经临床确诊为急性口血病的患者38例，缓解组25例，对照组35例进行MRI检查及T1值和对比度噪声比（CNR）的测定。结果：急性白血病T1WI:治疗前组38例,腰紙椎、酩骨及股骨近段均表现为信号降低;化疗缓解组25例表现为不同程度的信号增高。T2WI：38例治疗前组和25例化疗后组各椎体、骼骨、股骨上段呈等信号。外周血B%、骨髓B%、
2、腰椎T1值、腰椎/皮下脂肪CNR、股骨骨髓/皮下脂肪CNR于急性口血病治疗前组与正常对照组、治疗前组与缓解组间的差异均冇显着性（P<0.05）,缓解组与正常对照组间的差异无显着性（P>0・05）,不同细胞类型间的差异无显着性（P>0.05）。腰椎T1值于不同性别、年龄组间的差异无显着性（P>0.05）o治疗前组骨髓B%与腰椎T1值、与腰椎/皮卜•脂肪CNR,外周血B%与腰椎T1值、与腰椎/皮下脂肪CNR及腰椎T1值与腰椎/皮下脂肪CNR之间成直线相关（P<0.05）o结论：急性口血病的MRI检查为一种无创性方法，MRI表现具冇一定的特征性，在估计
3、病情的严重程度及治疗效果的评价简便实用，为避免多次重复骨髓穿刺检查以及全而观察急性口血病骨髓浸润范围和程度有着重要的临床意义。关键词：急性白血病磁共振成像（MRI）诊断治疗TheValeofMRIinacuteleukemianaturallyandquantitatively[Abstract]objectivcToevaluateMRIdiagnosisofbonenarrowinacuteleukemiabyobservingMRIappearanceandcalculatingT1value,CNR(ratioofcontrast/noi
4、se)inpatientsbeforeandafterchemothrapy,contrastingtomaterialsinclinicandpathology.MaterialsandmethodsThirty・eightpatients,withacuteleukemiawereexamined.Twenty-fivepatientsservedasremissiongroup.Ascontrolgroup,35healthyvolunteerswereperformedMRexaminationwithidenticalmethods.S
5、erialMRstudiesincludeobservationofMR!characterandmeasurementofT1valueandCNRinallpatients・ResultOfal138casesofacuteleukemiaatthetimeofdiagnosiscomparewithcontrolgroup:HypointensesignalinT1WIbywell-distributewerefoundinlumbosacralvertebral,iliac,andfemurapproaching.Isointcnscsi
6、gnalinT2WIwasfoundinallcaseswcdone.ThesignalintensityinT1WTtendedtonormalinal125remissioncasesofacuteleukemia・IsointcnscsignalalsofoundinT2WIinremissioncases・ThedifferenceofT1valueinlumber,CNRinlumber/subcutaneousfatandfemur/subcutaneousfat,B%inbloodandmarrowweresignificant(P
7、<0.05)amonggroupsofdiagnosisandcontrol,diagnosisandremission;buttheyweren,tsignificant(p>0.05)betweengroupsofcontrolandremission,andcellulalityamongALL,AML,ALL+AML.Positive1inearcorrelationwasfoundamongT1valuein1umberandB%inblood,T1valueinlumberandB%inmarrow,CNRinlumber/subcu
8、taneousfatandB%inblood,CNRin1umbe17subcutancousfatandB%inmarrow,T1va
