内科学中毒总论-邹和建

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1、DepartmentofMedicineHejianZOUDiseasesCausedbyPhysicalandChemicalFactors--Briefintroductionintroduction：Factorscausediseases：chemicalsphysicalbiologicalpsychologicalchemicals：occupational,non-occupational.physical：occupational,non-occupationalPhysicalfactors:MicrowaveVD

2、T(videodisplayterminal)Electromagneticfield……poisoningDefinition：Whatispoisoning?toxicantsdose-relatedhazardstothebodyChemicalsfrom：industrial、medicine、pesticide、plants、animalsOrganortissueinvolved)：cardiovascular、respiratory,nerve,liver,kidney,bloodCausation：occupational,

3、dailylifeOnset：acute,subacute,chronicmechanisms一、absorb,metabolicandexcretionoftoxicantsapproach：respiratorytract,occupationaldigestivetract,dailylifeskinlatex……metablism：liver－oxidation，deoxidize，hydrolyze，combinationeffects：decreaseorincreaseintoxicityexcretion：kidne

4、y，resp.trac.，diges.trac，latex，hair，nail二、toxicmechanisms1.irritation：acid,alkaline2．anoxic：3.anaesthesia：organicsolvent、anaesthetic4．inhibitofenzyme5．Effectsofcellmembraneorganelle6.Receptfunction三、whytoxication?1．toxicantsitself2．doseandduration3．susceptibilityClinicalman

5、ifestation一、acutepoisoningshortterm,largedose1．skinandmucosa2.respiratorysystem3．neurosystem4．Bloodsystem5．cardiovascularsystemarrhythmia，shock,heartfailure,suddendeath6.urinarytrac.hematuria,albuminuria7．liverdiseasecausebyintoxication8．others二、chronicpois.longterm,lowerd

6、ose1．Respiratorysystem2.neurosystem3.Bloodsystem4．Cardiovascular5．Urinary6．Liver7.othersdiagnosisanddifferentialdiagnosis1．toxicants2．manifestation(dose-effectiverelationship)3．laboratoryanalysis4.epidemiologicalstudytreatment一、principle：1．stopcontact2．Rescue:airway,bloodp

7、ressure,circulation)3.excretionoftoxicants4．Antidotestretment5．othertreatmentprevention一、propagandize二、safekeeping