纳洛酮治疗血管性痴呆

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1、纳洛酮治疗血管性痴呆纳洛酮联合嗤硫平治疗血管性痴呆叠加谢妄的对照研究莫新，胡耀祖，高丽娟［摘要］日的：探讨洛酮联合嗤硫平与单用嗤硫平治疗血管性痴呆叠加谑妄的疗效与疗效指数。方法：符合DSM-4血管性痴呆叠加请妄诊断标准的住院病人，随机分成治疗组(纳洛酮联合I蜚硫平)和对照组(I嗤硫平)，前瞻性观察治疗15d,采用谄妄量表(DSS)在治疗前及治疗3d、6d、9d、12d、15d进行评分。采用简易智力状态量表(MMSE)、日常牛活评定量表(ADL)及临床疗效总评量表(CGI)在治疗前和治疗15d后进行评分。结果：

2、治疗组与对照组对治疗血管性痴呆叠加请妄均有效、疗效指数高(CGI-GI分别为1・45±0・51、1.80±0.41,CGI-ET分别为3.32+0.48.2.95±0.22)。两组对比,治疗组的DSS增分在治疗3d、6d、9d、12d冇显著差异(p〈0.01)、在治疗15d时差异有统计学意义(p<0.05),治疗后MMSE增分、CGI-SI减分和CGI-GI的差异有统计学意义(p<0.05),CGI-EI有显著差异(p<0.01),ADL减分的差异没有统计学意义(P>0.05)。结论：在治疗血管性痴呆叠加诱妄

3、时，纳洛酮联合喳硫平较单用座硫平控制诱妄症状快，疗效和疗效指数更高，还能提高认知功能。［关键词］纳洛酮噪硫平血管性痴呆谢妄疗效疗效指数AcontrolstudyofdeliriumsuperimposedonvasculardementiatreatmentbetweenNdloxonejointQuetiapineandQuetiapinealoneMOXin,HUYaozu,GaolijuanThethirdpeoples'hospitalofFoShan,Foshan,Guangdong,528000［

4、Abstmct］ObjectiveToexploretheefficacyandefficacyindexofdeliriumsuperimposedonvasculdrdementiatreatmentwithNaloxonejointQuetiapineandQuetiapinealone.Methods42pationtswithdeliriumsuperimposedonvasculardementiawererandomlydividedintoQuetiapinegroup(n=20)andNal

5、oxonejointQuetiapincgroup(n二22),prospectiveobservationtreatmentcontinuedfor15days,beforeandaftertreatment,DSS,MMSE,ADLandCGIwererespectivelyusedtoevulate.ResultsBothNaloxonejointQuetiapineandQuetiapinealonetotherapydeliriumsuperimposedonvasculardementiaaree

6、ffectiveandtheirefficacyindexarehigh(CGI-GI：1.45±0.51、1.80±0.41,CGI-ET：3.32±0.48、2.95±0.22)•Comparingtwogroups,aftertreatmentfor3days、6days*9days^12days,theDssincreasepointsofNaloxonejointQuetiapinegroupwassignificantstatistically(p〈0.01).aftertreatment15da

7、ys,Dssincreasepointswassignificantstatistically(p<0.05),aftertreatment,MMSEincreasepoints、CGI-SIdeductionandCGI-GIhavestatisticallysignificance(p〈0・05),CGI-ElwassignificarUstatistically(p<0.01),ADLdeductionhavenostatisticalsignificancc(p>0.05)・ConclusionCom

8、paringtoQuetiapinealone,NaloxonejoinQuetiapinetotreatdeliriumsuperimposedonvasculardementiacancontroldeliriumfaster,hasahigherefficacyandefficacyindex,andimprovecognitivefunction.[Keywords]NaloxoneQuet