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时间:2019-09-23
《中晚期食管癌三维适形放疗联合同期化疗的临床观察》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、【摘要】目的:观察三维适形放疗联合同期化疗治疗中晚期食管癌的丢副反应与临床疗效。方法:62例符合入纽条件的中晚期食管癌患者接受三维适形放疗及同期化疗。放疗处方刑童60Gy/30次•化疗选择LFP方案•观察总者的治疗完成情况、放化疗奉副反应及临床疗效。结果:1)61例患者如期完成放疗,化疗完成$3个周期者29例.完成2个周期者18例•仅完成1个周期者15例。2)治疗的急性毒性反应主要为骨髓抑制和胃肠道反应,其中胃肠道反应总发生率为79.03%(49/62)・白细胞减少总发生率为80.65%(50/62),急性
2、放射性食管炎总发生率为80・65%(50/62几其中以1级和2级占8&00%(44/50)o急性放射性肺炎的总发生率为3&71%(24/62).其中1级占54.17%(13/24)。3)全组患者1、2和3年局控率分别为89.97%、70・66%和70・66%,1、2和3年生存率分别为8&33%、55・78%和52.68%•中位生存期28个月.GTV最尢横径W4cm组与>4cm组1.2和3年生存率分别为96.88%.74.27%、68.08%和78.57%、34・83%、34・83%.£=7.48,P=0.0
3、062.结论:三址适形放疗联合I.FP方案同期治疗中晚期食管癌几有可行性.多敏总才能耐受,该种治疗模式初步取得了较满意的厉农:樂及生存率•临床疗效有提高的她势,远处转移的控制未见改善.中华肿榆防治杂>2O1OJ7(24).2053-2056•2053•中华肿描防治杂志20】0年12月第17卷第24期CHINJCANCERPREVTREAT.Decemb"2010.VoL17No.24(临床应用研究)中晚期食管癌三维适形放疗联合同期化疗的临床观察王澜,韩春,李晓宁,高超,呂冬婕河北医科大学第四医院放疗科,河北
4、石家庄050011Three-dimensionalconformalradiotherapycombinedwithconcurrentchemotherapyforlocallyadvaneedesophagealcarcinomaWANGLan5、.China[ABSTRACT]OBJECTIVE:Toobservetheacutesideeffectsandclinicalresultsofthree-dimensionalconformalradiotherapy(3DCRT)combinedwithchemotherapyforesophagealcarcinoma.METHODS:Totally62patientswithesophagealcarcinomareceived3DCRTcombinedwithconcurrentchemot6、herapyofLFP.Thesideeffectsandclinicalresultswereobserved.RESULTS:1)Ofallthepatients^6]completedradiotherapy<29patientscompleted3ormorethan3cyclesofchemotherapy•18completed2cyclesand15completedonly1cycle.2)Theacutetoxicreac・tionsweremarrowdepressionandgastr7、ointestinaltractreactionmainly•49(79.03%)patientsdevelopedthesideeffectsofnausea>vomitingandconstipation•andtheincidenceofleucopeniawas80.65%(50/62).Fiftypatients(80.65%)developedacuteradiationesophagitiswith88.00%(44/50)ofgrade1andgrade2.and24patients(38.8、71%)developedacuteradiationpneumonitiswith54.17%(13/24)ofgrade1.3)The1-t2->3-yearlocalcontrolrateswere89.97%.70.66%and70.66%•respectively.Thel->2-13-yearoverallsurvivalrateswere8&33%.55.78%and52.68%.respectiv
5、.China[ABSTRACT]OBJECTIVE:Toobservetheacutesideeffectsandclinicalresultsofthree-dimensionalconformalradiotherapy(3DCRT)combinedwithchemotherapyforesophagealcarcinoma.METHODS:Totally62patientswithesophagealcarcinomareceived3DCRTcombinedwithconcurrentchemot
6、herapyofLFP.Thesideeffectsandclinicalresultswereobserved.RESULTS:1)Ofallthepatients^6]completedradiotherapy<29patientscompleted3ormorethan3cyclesofchemotherapy•18completed2cyclesand15completedonly1cycle.2)Theacutetoxicreac・tionsweremarrowdepressionandgastr
7、ointestinaltractreactionmainly•49(79.03%)patientsdevelopedthesideeffectsofnausea>vomitingandconstipation•andtheincidenceofleucopeniawas80.65%(50/62).Fiftypatients(80.65%)developedacuteradiationesophagitiswith88.00%(44/50)ofgrade1andgrade2.and24patients(38.
8、71%)developedacuteradiationpneumonitiswith54.17%(13/24)ofgrade1.3)The1-t2->3-yearlocalcontrolrateswere89.97%.70.66%and70.66%•respectively.Thel->2-13-yearoverallsurvivalrateswere8&33%.55.78%and52.68%.respectiv
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