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1、ThyroidcancerdetectionsignificanceofBcl-2[Abstract]ObjectiveToinvestigatetheexpressionofBcl-2intheincidenceofthyroidcancer,developmentandprognosis.Methodsimmunohistochemicalmethods,mouseanti-humanmonoclonalantibodiestoBcl-2mark77casesofthyroidcancer,
2、58casesofthyroidadenomaand40casesofadjacentthyroidtissueand28casesofnormalthyroidtissue.observethedifferentthyroidtissueexpressionofBcl-2,andcomparethepositiverateofBcl-2positiveresultsseeninthyroidcancer,thyroidadenomaandadjacentthyroidtissue.inthyr
3、oidcarcinomaBcl-2positiveratewas45.5%,higherthanthethyroidadenoma(22.4%)(P=0.006),adjacentthyroidtissue(17.5%)(P=0.003)andnormalthyroidOrganizations(0)(P=0.000).anaplasticthyroidcarcinomaandfollicularcarcinomaoftheBcl-2positiveratewassignificantlyhig
4、her.presencelymphnodemetastasisandclinicalstageⅢ,Ⅳcases,Bcl-2positiveratesignificantlyincreased.ConclusionsBcl-2overexpressionmaybeassociatedwiththeoccurrenceofthyroidtumors,cancertissueexpressionofBcl-2canbeusedasareferenceindicatorofthyroidcancerpr
5、ognosis. [Keywords:]ThyroidCancer,Bcl-2Gene,Proto-Oncogenes,GeneExpression,ImmunohistochemistryThyroidcancerisacommonendocrinecancer,womenwithahighincidenceofclinicalthyroidtumorsin5%to10%ofthyroidcancer[1]whichdifferentiatedthyroidcanceraccountsfor9
6、0percent,includingpapillarythyroidcarcinomaandfollicularthyroidcarcinoma,undifferentiatedcarcinomaarerare,itshighdegreeofmalignancyandpoorprognosis.domesticdatashowthattheincidenceofthyroidcancerinasignificantincreasein[2]Inrecentyears,thyroidcancer-
7、relatedgenesandtumormarkerstudiesprogressedveryquickly.studyconfirmed[3,4],Bcl-2geneisanapoptosissuppressorgene,firstdiscoveredinfollicularB-celllymphomas,anditsproductBcl-2proteininhibitsapoptosisandprolongcellsurvival.TheStudiesusingimmunohistochem
8、icaltechniques,bydetectingBcl-2inthyroidcancer,thyroidadenoma,thyroidcancertissueandnormalthyroidtissuelevelsofBcl-2studyinthyroidcancerincidenceinthedevelopmentprocessroleinordertorevealtheBcl-2andthyroidcancerbiologicalbehaviorandprognosisofrelatio
