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1、原发性胆汁性肝硬化的实验研究第二军医大学长征医院实验诊断科中国人民解放军医学免疫诊断中心仲人前Email:rqzhong@yahoo.comWebsite:www.clinimmunchina.com1AMAHistologyAMAHep-2细胞Anti-centromereAnti-nuclearmembraneAnti-nucleardots2naturalhistoryofPBC3SelmiC,Lancet2011;377:1600–09ductopeniaandfibrosisinPBC70-85%10-20%5-10%4PouponR.Journal
2、ofHepatology2010;52:745–758PapersonPBC200018001600140012001000800600400200OnMedline01945-19491950-19541955-19591960-19641965-19691970-19741975-19791980-19841985-19891990-19941995-19992000-20042005-2009700600500InChinese40030020010001945-19491950-19541955-19591960-19641965-19691970-1
3、9741975-19791980-19841985-19891990-19941995-19992000-20042005-2009567randomizedcontrolledtrial8910111213PBCrelatedfactorsCorpechotC,Demographic,lifestyle,medicalandfamilialfactorsassociatedwithprimarybiliarycirrhosis.14JHepatol2010;53:162–169Annualincidenceandprevalence/100,000ofPBC
4、StudyYearCaseno.IncidencePrevalenceMethodsSheffield,UK1980340.585.4PS,AMAMalmo,Sweden1984331.49.2HREASL19845690.40.5–7.5PSOrebro,Sweden1985361.412.8AMANewcastle,UK19893471.1–1.915.4PS,AMA,HROntario,Canada19902060.332.2PSUmea,Sweden1990861.315.1PS,AMA,HRVictoria,Australia199384NA1.9P
5、S,AMA,HREstonia1995690.232.7PS,HRJapan199512580.34–0.422.0HR,AMANewcastle,UK19971602.218–24PS,AMA,HROslo,Norway1998211.614.6HRNewcastle,UK19997703.125.1PS,HR,AMAOlmstead,USA2000462.740.2PS,AMA,HR15PBCinChinamainlandYearPBCcaseNoteIncidence/10000020016/200abnormalliverfunction3000200
6、221/1412hospitalized148720043/5011annualphysicalexam6020104/8126annualphysicalexam49.2women>40Yrs155.8600000-800000PBC!!!JiangXH,WorldJGastroenterol,2003,9(6):1352-516LiuHY,BMCGastroentol2010;10:100PBCinseasonsMcNALLYRJQ,SeasonalVariationintheDiagnosisofPrimaryBiliaryCirrhosis:Furth
7、erEvidenceforan17EnvironmentalComponenttoEtiology.Hepatology2011;Factorspossiblyentailedinonsetandperpetuationofbile-ductinjuryinPBC18SelmiC,Lancet2011;377:1600–09PBCsequentialevents19PouponR.JHepatol2010;52:745–758FamilialprevalenceofPBC2021Humanleukocyteantigen(HLA)complexonhumanc
8、hromosome622h23PBC与
