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1、依那普利、美托洛尔联合治疗慢性心力衰竭的临床观察［摘要］目的探讨依那普利、美托洛尔联合治疗慢性心力衰竭的临床应用效果。方法选取2014年6月〜2016年6月我院住院治疗的慢性心力衰竭患者80例作为研究对象，随机分为两组，每组40例。对照组采取常规强心、利尿、扩血管等强心治疗，观察组同时予以依那普利、美托洛尔联合进行治疗，6个月为一个疗程。若有心绞痛或心肌缺血者应用硝酸酯类药物治疗。治疗半年后观察患者的心功能左室射血分数（LVEF）的变化情况，并对两组的临床疗效进行对比分析。结果观察组患者的总有效率显著高于对照组，差异具有统计学意义（P
2、<0.05）o观察组患者治疗后的LVEF较对照组显著提高，差异具有统计学意义（P<0.05）o结论对于慢性心力衰竭患者在常规强心、利尿、扩血管等强心治疗的基础上同时予以依那普利、美托洛尔联合进行治疗，可以显著提高临床疗效，且明显改善患者的心功能，从而有利于提高患者的生活质量，促进疾病尽快恢复。［关键词］慢性心力衰竭；依那普利；美托洛尔；联合治疗［中图分类号］R541.6［文献标识码］B［文章编号］1673-9701(2017)09-0056-03Clinicalobservationofenalaprilandmetoprololin
3、thetreatmentofchronicheartfailureDUWeiyuanDepartmentofCardiology,ChangleCountyPeople'sHospitalinShandongProvince,Changle262400,China[Abstract]ObjectiveToinvestigatetheclinicaleffectofenalaprilandmetoprololinthetreatmentofchronicheartfailure.Methods80patientswithchronich
4、eartfailuretreatedinourhospitalfromJune2014toJune2016wererandomlydividedintotwogroups,40casesineachgroup.Thecontrolgroupwastreatedwithconventionalcardiac,diuretic,vasodilatorandothercardiactherapy,theobservationgroupwastreatedwithenalaprilandmetoprolol,6monthsasacourseo
5、ftreatment.Patientswithanginapectorisormyocardialischemiaweretreatedwithnitrates.Thechangesofleftventricularejectionfraction(LVEF)wereobservedaftertreatmentsixmonths,andtheclinicalefficacywascomparedbetweentwogroups.ResultsThetotaleffectiverateoftheobservationgroupwassi
6、gnificantlyhigherthanthatofthecontrolgroup,thediffereneewasstatisticallysignificant(P<0.05).TheLVEFoftheobservationgroupaftertreatmentwassignificantlyhigherthanthatofthecontrolgroup,thedifferencewasstatisticallysignificant（P<0.05）.ConelusionForpatientswithchronicheartfa
7、ilureonthebasisofconventionalcardiac,diureticandvasodilatortherapyoncardiaccombindenalaprilandmetoprololtreatment,cansignificantlyimprovetheclinicalefficacy,andsignificantlyimprovethepatient'sheartfunction,whichhelpstoimprovethequalityoflifeofpatients,promotediseasereco
8、veryassoonaspossible.[Keywords]Chronicheartfailure；Enalapril；Metoprolol；Combinedtherapy慢性心力衰竭是由于各？N心脏结构或功能性疾病导
