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1、高血压合并颈动脉硬化中医证型和颈动脉斑块和脂联素水平相关性探究摘要：目的探讨高血压合并颈动脉硬化中医证型与脂联素水平及颈动脉斑块的关系，为临床诊疗提供客观依据。方法将100例高血压合并颈动脉硬化患者辨证分为痰证组、瘀证组、痰瘀互结证组，并与健康对照组30例进行比较。采用GELOGIQ500型多功能彩超诊断仪检测颈动脉斑块形成情况，采用酶联免疫吸附法(ELISA)测定血清脂联素(APN)水平。结果痰瘀互结证组APN水平显著低于其他组,各组APN水平差异有统计学意义；痰瘀互结证组形成斑块较多见。颈动
2、脉内膜-中层厚度(IMT)与APN呈负相关。结论高血压合并颈动脉硬化患者中医证型与APN及颈动脉斑块有一定相关性,根据中医证型可初步判断其APN的异常变化及斑块形成情况。关键词：高血压；颈动脉硬化；中医证型；脂联素D0I：10.3969/j.issn.1005-5304.2013.08.008中图分类号：R259.441；R259.435文献标识码：A文章编号：1005-5304(2013)08-0021-03CorrelationshipbetweenTCMSyndromesandCaroti
3、dAtherosclerosisPlaque,AdiponectinLevelofHypertensionComplicatedwithCarotidAtherosclerosisCHANJin-shui,WUTian-min,FANLiu-fang,HUANGYan-jin(TheFirstAffiliatedHospitalofFujianMedicalUniversity,Fuzhou350005,China)Abstract:ObjectivesTostudytherelationshi
4、pbetweenTCMsyndromesandadiponectin(APN)level,carotidatherosclerosisplaqueofhypertensioncomplicatedwithcarotidatherosclerosis,andprovideevidenceforclinicaldiagnosisandtreatment・MethodsOnehundredpatientsofhypertensioncomplicatedwithcarotidatheroscleros
5、isweredividedintophlegmsyndromegroup,stasissyndromegroup,andintermingledphlegmandbloodstasissyndromegroup,andcomparedwith30healthypeopleascontro1.CarotidatherosclerosisplaquewasdetectedwithGEL0GIQ500colorultrasoundsystem.ELISAwasusedtodeterminetheser
6、umAPN.ResultsAPNoftheintermingledphlegmandbloodstasissyndromegroupwasobviouslylowerthanothergroups,andtherewereobviousdifferencesamongthem.Thereweremoreplaquesintheintermingledphlegmandbloodstasissyndromegroup.Anegativecorrelationshipwasshowedbetween
7、carotidarteryintimamediathickness(IMT)andAPNofhypertensioncomplicatedwithcarotidatherosclerosis・ConelusionThereiscorrelationbetweenTCMsyndromeandAPNlevel,carotidatherosclerosisplaqueofhypertensioncomplicatedwithcarotidatherosclerosis・Theanomalouschan
8、geofAPNandplaqueformationofthepatientscanbepreliminarilyestimatedwiththesyndromeofTCM.Keywords：hypertension；carotidatherosclerosis；TCMsyndrometype；adiponectin动脉粥样硬化(atherosclerosis,AS)是多种心脑血管疾病的病理基础。颈动脉是AS的好发部位，高血压合并颈动脉硬化是脑卒中和冠心病的主要危险因素之一。AS与脂质代谢紊乱密切
