喘可治注射液对中、重度COPD患者血气分析及肺功能的影响

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1、喘可治注射液对中、重度COPD患者血气分析及肺功能的影响陈功等•喘可治注射液对中，重度COPD患者血气分析及肺功能的影响?429?喘可治注射液对中，重度COPD患者血气分析及肺功能的影响陈功，曾玉琴,朱建勇h,王永兰(鄭阳医学院附属人民医院呼吸科;太和医院内分泌科，湖北十垠442000)［摘要］目的:观察喘可治注射液对中，重度慢性阻塞性肺疾病(COPD)患者血气分析及肺功能的影响•方法：屮，重度COPD急性加重期患者被随机分为两组，对照组43例给予常规治疗;治疗组41例在前者基础上加用喘可治注射液•比较两组不同时期的血气分析，肺功能变化及半年内急性加重次数.结

2、果：第7天时治疗组血气改善明显，第7,14天时的肺功能好转显着(P均<0.05);第60天时两组肺功能都明显下降，但在治疗组下降的幅度相对较少(P均<0.001);治疗组患者半年内急性加重(1.7±0.3)次，显着低于对照组(2.24-0.5)次(P<0.001).结论:喘可治注射液有助于改善中，重度COPD患者急性加重期肺功能.［关键词］喘可治;慢性阻塞性肺疾病冲图法分类号］R563［文献标识码］A［文章编1006-9674(2008)05-0429-03EffectsofChuankezhilnjeefiononBloodGasAnaly

3、sisandPulmonaryFunctionofPatientswithModerate-SevereCOPDCHENGong,ZENGYu—qin,ZHUJian?yong,WANGYong—lan.(.DepartmentofRespiratoryDe,RenminHo〜itd,DepartmentofEndocrinology5TaiheHospital,YunyangMedicalCollege,Shiyan,Hubei442000,China)Abstract:ObjectiveToobservetheeffectofchuankezhiinjec

4、tiononbloodgasanalysisandpulmonaryfunctionofpatientswithmoderate-severeperiodchronicobstructivepulmonarydisease(COPD).MethodsThemoderate一severeCOPDpatientsduringacuteexacerbationwererandomlydividedintocontrolgroup(n:43)andtreatmentgroup(n=41).ConventionaltherapyWasadministeredforthe

5、twogroups.thechuankezhiinjectionwasusedinthetreatmentgroupadditionaly.Bloodgasanalysisandpulmonaryfunctionduringdifferentperiods^thenumberofacuteexacerbationcorrelatedwithCOPDinhalfyearwerecomparedbetweenthetwogroups.ResultsOnthe7thday,bloodgasanalysisinthetreatmentgroupwassignifica

6、ntlyimprovedthanthatofcontrolgroup,onthe7thandl4thdaythepulmonaryfunctioninthetreatmentgroupwassignificantlyimprovedthanthatofcontrolgroup(P<0.05);0nthe60thdaythepulmonaryfunctionwasbothdecreasedinthetwogroups,whileinthetreatmentgroupthedecreaseextentWaslowerthanthoseincontrolgro

7、up(P<0.001);Thenumberofa一cuteexacerbationcorrelatedwithCOPDinhalfyearintreatmentgroupwassignificantlylowerthanthatincontrolgroup[(1.7±0.3)VS(2.5±0.5)times,P<0.001].ConclusionChuankezhiinjectioncouldimprovepulmonaryfunctionofthemoderate—severeCOPDpatientsduringacuteexacerbation

8、.Keywords:Chuankezh