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1、人群接种A+C群脑膜炎球菌多糖疫苗后安全性和免疫原性研究社区医学杂志2008年第6卷第11期人群接种A+C群脑膜炎球菌多糖疫苗后安全性和免疫原性研究王信(翔城县卫生防疫站山东翔城276100)［摘要］目的以分组对照法观察A+c群脑膜炎球菌多糖疫苗对6〜24月龄幼儿和5〜13岁儿童接种后的安全性和免疫原性.方法观察组共428名儿童，分为2个年龄段接种A+c群脑膜炎球菌多糖疫苗,接种剂量为每人lOOi.Lg;阳性对照组103人接种A群脑膜炎球菌多糖疫苗，接种剂量为每人50i.Lg;阴性对照组94人接种伤寒Vi多糖疫苗，接种剂
2、量为每人30g.各组于接种后6,24,48和72h测量体温并观察全身和局部反应,并于免疫前，后1个月分刚收集血清标本,观察组2个年龄段儿童各不少于50名于免疫后6个月和1年再次收集血清标本，免疫前后收集到的血清采用体外杀菌力试验方法进行杀菌抗体水平的测定.结果疫苗接种后人体反应轻微,428名儿童仅有3名(0,7%)出现中，强发热反应，有4名(0,9%)出现局部红晕,48h后反应全部消失.5〜13岁儿童组免疫后1个月抗A和C群脑膜炎球菌杀菌抗体4倍增长率分别为96,59%,92.15%,免疫后1年的4倍增长率仍保持在90.
3、91%和90.08%.结论A+c群脑膜炎球菌多糖疫苗接种后具有较好的安全性和免疫原性.［关键词］疫苗;A+c群脑膜炎球菌多糖;安全性晚疫原性;杀菌抗体，［中图分类号］R186［文献标识码］A［文章编#］1672—4208(2008)11一0006—04StudyonthcSafctyandlmmunogcnicityofUroupA+CMcningococcalPolysaccharidcVaccincWANGXin.TheCenterforDiseaseControlandPreventioninTancheng,Ta
4、ncheng276100,China［Abstract］ObjectivelnordertoevaluatethesafetyandimmunogenicityofgroupA+Cmeningococcalpolysaccharidevaccine,acontrolledfieldtrimwasperfbnnedamongchildrenat6〜24monthsand5〜13ycarsoldinTanchengcounty.MethodsMorethan600childrenwereselectedinthistrial
5、.428children.aged6〜24monthsoldand5〜13year一oldwereinvolvedintwoexperimentalgroupsandwereinoculated1OOgofgroupA+Cmcningococcalpolysaccharidcvaccinc.103childrcninpositivccontrolgroupwcrcinoculatcd50gofgroupAmeningococcalpolysaccharidevaccinewhile94childreninnegative
6、controlgroupwereinoculatcd30gofTyphoidVipolysaccharidcvaccinc.Bothsystcmicandlocalrcactionswcrcobscrvcdincachgroupat6h,24h948hand72hafterinoculation.Bloodsampleswerecollectedinallchildrenbefbreandlmonthafterinocu
7、a.tion.Additionally,atleast50bloodsamplesweretaken
8、ineachexperimentalgroupat6andl2monthsafterin.oculation.Serumbactericidalantibodywastestedbymicrobactericidaltest.ResultsBothsystemicandlocalreactionsweremildintwoexperimentalgroupswithonly3children（0.7%）had>37.6~Cfever,4children（0.9%）appcarcdmildarcolabutalladvcr
9、scrcactiondisappcarcdwithin48hours.In5〜13year~ldexperi.mentalgroup,theratesfbrfbur—fbldincreaseofbactericidalantibodywere96.59%and92・15%togi・oupAandgroupCmenin
