病原性球菌pathogenic cocci

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1、1.Pathogeniccocci2.Otherbacteria1.PathogeniccocciConceptofpathogenicbacteria13minStaphylococcus(Esp.,S.aureus)56minStreptococcus(Esp.,S.pyogenes)38minEnterococcusspeciesandVRE5minNeisseriameningitidesNeisseriagonorrhoeae13min2.OtherbacteriaPseudomonasaeruginosa10minHig

2、hlightsofcontentUptoeverypathogen,thefollowingwillbetalked:BiologicalpropertiesPathogenicityImmunityMicrobiologicaldetectionsPreventionandtreatmentPustule(脓疱)byS.aureusPustule(脓疱)byS.aureusParonychia(甲沟炎)byS.aureusSorethroat(咽喉炎)byS.pyogenesUntreatederysipelas(丹毒)byS.p

3、yogeneswithskinsloughingandnecrosisNecrotizingFasciitis(坏死性筋膜炎)byflesh-eatingbacteria(S.pyogenes,anaerobicbacteria,etc.),andinsects(bee,etc.)stingingChestx-rayFilm1justafewhoursofrigorsandproductivecoughChestx-rayFilm212hourslaterconsolidationintherightupperlobeLobarpn

4、eumonia(大叶性肺炎)byS.pneumoniaeMeningococcalsepticemia(脑膜炎球菌性败血症)byN.meningitidis,widespreadecchymosesGonococcalconjunctivitis(淋菌性结膜炎)byN.gonorrhoeaeCausativeagentsofaboveclinicaldiseases?PathogeniccocciWhatisPathogeniccocci?alsocalled—Pyogeniccocci(化脓性球菌)Including—---Sta

5、phylococcus(S.aureus&S.epidermidis)(金黄色葡萄球菌与表皮葡萄球菌)---Streptococcus(GroupAStreptococci,S.pyogenes)(A群链球菌or化脓性链球菌)---Streptococcuspneumoniae(肺炎链球菌)---Neisseriagonorrhoeae(淋病奈瑟菌)---Neisseriameningitidis(脑膜炎奈瑟菌)ImportantcocciGramstainBacterialgeneraG+GenusstaphylococcusGe

6、nusstreptococcusG-GenusNeisseria(N.meningitidesN.gonorrhoeae)StaphylococcusaureusImportantpyogeniccoccusLeadingpathogenofwoundinfections(includingotherstaphylococci)Shape,Stain&Culturespherical,elliptical,irregulargrape-likeclusterGram+(G+)GrowwellonbasicmediumBiologic

7、alpropertiesAntigenicstructureStaphylococcalproteinA(SPA)OnekindofsurfaceproteinincellwallSinglechainpeptideActions—Binds(bacterium)tohost’sIgG1,IgG2&IgG4coagglutinationtestCompetesw/FcreceptorsofphagocytesresistsphagocytosisCoagglutinationtestwithinertparticles(e.g.,h

8、eat-killedS.aureusorlatexbeads)SPAmayresistphagocytosisbycompetivelybindingwithFcreceptorsofphagocytesCapsuleTeichoic