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ID:41666140
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页数:11页
时间:2019-08-29
《孕妇抗磷脂抗体胰岛素样生长因子-I与胎儿生长受限的相关性研究》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、孕妇抗磷脂抗体胰岛素样生长因子-I与胎儿生长受限的相关性研究[摘要]目的探讨胎儿生长受限(FGR)孕妇抗心磷脂抗体(ACA)与胎盘组织胰岛素样生长因子-I(IGF-I)表达水平间的关系及两者在FGR发生中的作用。方法采用酶联免疫吸附法(ELISA法)测定63例正常足月妊娠孕妇(对照组)及63例胎儿生长受限孕妇(研究组)血清中ACA-IgG、IgM;利用免疫组织化学方法及多媒体彩色病理图像分析技术测定胎盘组织IGF-I表达水平。结果研究组抗心磷脂抗体阳性率为19.0%,对照组为3.2%,两组比较,有显著性差异(P<0.
2、05);研究组胎盘组织IGF-1表达水平明显低于对照组(PV0.05);ACA阳性组与ACA阴性组两组比较,胎盘组织IGF-I表达水平无显著差异(P>0.05),胎盘重量、胎儿体重有显著差异(PV0.05)。结论孕妇血清ACA阳性或胎盘组织IGF-I表达水平下降是导致FGR的危险因素之一,ACA是否也会导致胎盘组织IGF-I表达水平下降有待进一步研究。[关键词]胎儿生长受限;胰岛素样生长因子I;抗心磷脂抗体[中图分类号]R714.5 [文献标识码]A
3、 [文章编号]2095-0616(2014)08-13-03Correlationstudyofpregnantwomen'santiphospholipidantibodyandinsulin-likegrowthfactorIandfetalgrowthrestrictionBAN Zhenghe1 LI Lichang1 WENG Biyan21.GuangzhouBaiyunDistrictFirstPeopl
4、e'sHospital,Guangzhou510410,China;2.GuangzhouBaiyunDistrictRedCrossHospital,Guangzhou510545,China[Abstract]ObjectiveToinvestigatetherelationshipbetweenthepregnantwomen'sexpressionlevelsofanti-cardiolipinantibody(ACA)andplacentaltissueinsulin-likegrowthfactor-1(
5、IGF-I)andtheirroleinfetalgrowthrestriction(FGR).MethodsTheenzyme-linkedimmunosorbentassay(ELISA)wasusedtodetecttheserumACA-IgGandIgMof63pregnantwomenwithnormalfull-termpregnancy(controlgroup)and63patientswithfetalgrowthrestriction(studygroup);Theimmunohistochem
6、icalmethodandmultimediacolorpathologicalimageanalysistechniquewereusedtomeasuretheIGF-Iexpressionlevelinplacentatissues.ResultsThepositiverateofACAinthestudygroupwas19.0%andthatinthecontrolgroupwas3.2%,withsignificantdifferencebetweenthetwogroups(P<0.05);Thestu
7、dygroupwassignificantlylowerthanthecontrolgroupintheIGF-Iexpressionlevelinplacentatissues(P<0.05);TheACApositivegroupandtheACAnegativegroupwerenotsignificantlydifferentintheIGF-Iexpressionlevelinplacentatissues(P>0.05),butweresignificantlydifferentinplacentawei
8、ghtandfetalbodyweight(P<0.05).ConclusionPositiveserumACAordecreasedIGF-IexpressionlevelsinplacentatissuesofthepregnantwomenisoneoftheriskfactorsofFGR.WhetherACAcandecreaseth
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