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1、SyntheticBiomaterialsMimicCellularMembranes:UseinNanomedicine,DrugDelivery合成生物材料模拟细胞膜:用于纳米医学药物输送ScienceDaily(May23,2010)—AninternationalcollaborationledbychemistsandengineersfromtheUniversityofPennsylvaniahaspreparedalibraryofsyntheticbiomaterialsthatmimiccellularmembranesandthatsh
2、owpromiseintargeteddeliveryofcancerdrugs,genetherapy,proteins,imaginganddiagnosticagentsandcosmeticssafelytothebodyintheemergingfieldcallednanomedicine.每日科学(2010年5月23日)-一个由美国宾州大学的化学家和工程师领导的国际合作小组制备了许多合成生物材料,这些生物材料能模拟细胞膜,且在新兴的纳米医学领域有目的得向人体安全输送抗癌药物,基因疗法,蛋白质,成像诊断试剂,化妆品等方面很有前景。Thestudy
3、appearsinthecurrentissueofthejournalScience.这项研究发表在最近一期的科学杂志上。Theresearchprovidesthefirstdescriptionofthepreparation,structure,self-assemblyandmechanicalpropertiesofvesiclesandotherselectedcomplexnano-assembliesmadefromJanusdendrimers.该研究对这些囊泡和其他由贾纳斯人造分子组成的复杂纳米聚合物的制备、结构、自组装性及其医学性能做
4、了首要说明。Theso-calleddendrimersomesarestable,bilayervesiclesthatspontaneouslyformfromtheexactchemicalcompositionofJanusdendrimers.这些所谓的人造分子成分是稳定的双分子囊泡,它们自动地由贾纳斯人造分子的精确化学成分转化形成。Theteamreportedamyriadofbilayercapsulepopulations,uniforminsize,stableintimeinalargevarietyofmediaandtemperat
5、ures,thataretunablebytemperatureandchemistrywithsuperiormechanicalpropertiestoregularliposomesandimpermeabletoencapsulatedcompounds.该团队报告的是一系列双分子层小囊泡状群体。它们在各种媒质和温度中大小统一,时间稳定。它们会随温度和化学过程调整,且在化学性能上比稳定脂质体和非渗透性封装化合物更加优越。Theyarecapableofincorporatingpore-formingproteins,canassemblewiths
6、tructure-directingphospholipidsandblockcopolymersandofferamolecularperipherysuitableforchemicalfunctionalizationwithoutaffectingtheirself-assembly.它们能结合成孔蛋白,能与引导结构此鞥成的磷脂和嵌段共聚物结合,并在不影响其自组装性的前提下与周边分子适合以达到化学官能化。Co-authorsVirgilPercecofPenn'sDepartmentofChemistryandDanielA.HammerofPenn
7、'sDepartmentofBioengineering,joinedbyFrankBatesandTimothyLodgeoftheUniversityofMinnesota,MichaelKleinofTempleUniversityandKariRissanenoftheJyväskyläUniversity,inFinland,havechemicallycoupledhydrophilicandhydrophobicdendronstocreateamphiphilicJanusdendrimerswitharichpaletteofmorphol
8、ogiesincludingcubosomes,di